期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 610, 期 -, 页码 913-922出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.11.146
关键词
Film-based band-aid; Wearable; pH-sensing; PDT/PIT; Wound healing
资金
- Talented Program [A279021724]
- Chinese Universities Scientific Fund [2452021123]
In this study, a bacteria-triggered wearable film-based band-aid was developed for monitoring and treating wound infection. The band-aid can detect and control infection quickly through color changes and photothermal/photodynamic therapy, and showed promising therapeutic effects in experiments.
Early diagnosis of bacterial infection and tracking of treatment effect are of great importance for developing a sense-and-treat integrated system. Herein, we developed a bacteria-triggered, portable, wearable and colorimetric film-based band-aid (FBA) for closed-loop monitoring and light-controlled therapy of wound infection. FBA with high photothermal conversion efficiency of 52.56% was prepared by wrapping Bi2S3 nanoflowers (BS NFs) loaded with rhodium nanoparticles (Rh NPs) and bromothymol blue (BTB) into LB agar film, integrating bacteria-triggered color change, photothermal/photodynamic therapy (PTT/PDT) synergistic bactericidal therapy and agar-based band aid in one intelligent system. Initially, FBA effectively simulates the pH sensing mechanism, and monitors the occurrence of bacterial infections within 5 min through color changes of Staphylococcus aureus (S. aureus) from blue to yellow and Escherichia coli (E. coli) from yellow to blue. Additionally, the short-term and controlled antibacterial strategy of one light dual-mode responses (photothermal and photodynamic responses) was implemented with the introduce of near-infrared (NIR). Ultimately, the effectiveness of FBA was fully validated in the monitoring and treating of S. aureus-infected mouse wounds. Notably, the designed FBA decisively abandoned off-target side effects maximizing the treatment effect and nakedly tracking therapeutic situation in real time, contributing an effective antibacterial alternative strategy for reducing the use of antibiotics. To the best of our knowledge, such integrated system is still unreported on film-fixed model. In view of the advantages of the low cost and convenience of the simple device, the integrated design is expected to provide a solution for the development of a closed-loop biomedical system combining diagnosis and treatment. (C) 2021 Elsevier Inc. All rights reserved.
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