4.7 Article

Disulfiram-loaded metal organic framework for precision cancer treatment via ultrasensitive tumor microenvironment-responsive copper chelation and radical generation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Tumor-responsive copper-activated disulfiram for synergetic nanocatalytic tumor therapy

Hao Chen et al.

Summary: The study showcases a sophisticated strategy for tumor-responsive nontoxic-to-toxic therapeutic by utilizing HKUST nMOFs as Cu(2+) self-supplying nanocarriers for efficient delivery of the DSF drug. The mild acidic condition of the tumor microenvironment triggers the release of Cu ions from HKUST nMOFs, which further react with DSF to form toxic Cu(DDTC)2(activation) for tumor chemotherapy, demonstrating dominant anticancer efficacy with satisfied biocompatibility both in vitro and in vivo.

NANO RESEARCH (2021)

Review Chemistry, Multidisciplinary

Cyclodextrins-modified metallic nanoparticles for effective cancer therapy

Sahil Gandhi et al.

Summary: The use of cyclodextrin-complexed metallic nanoparticles as a novel platform for cancer therapy can effectively overcome limitations of conventional chemotherapy. This approach improves the delivery efficiency of anticancer drugs, reduces toxic side effects, and holds great potential for clinical application.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Medicine, Research & Experimental

Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids

David A. Murphy et al.

Summary: The study utilized MnO2 NPs to catalyze the degradation of tumor-produced hydrogen peroxide and generate oxygen, effectively addressing hypoxia in solid tumors, reducing immunosuppression, and enhancing NK cell cytotoxicity. Encapsulation of MnO2 NPs into PLGA to form PLGA-MnO2 NPs particles improved biocompatibility and modulation of oxygen production for potential use in adoptive NK cell therapy.

MOLECULAR PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

A dual enzyme-mimicking radical generator for enhanced photodynamic therapy via series-parallel catalysis

Zhenbang Cao et al.

Summary: A dual enzyme-mimicking radical generator has been developed to enhance the efficacy of photodynamic therapy by in situ generation of oxygen and radical oxygen species. The metal organic framework-based radical generator nanoparticles exhibit catalase-like and peroxidase-like activities specifically at the tumor microenvironment, leading to increased reactive oxygen species levels and improved anti-cancer effects.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

Pan Zheng et al.

CHINESE CHEMICAL LETTERS (2020)

Article Chemistry, Multidisciplinary

Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization

Bowen Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Chemistry, Multidisciplinary

Developing New Cancer Nanomedicines by Repurposing Old Drugs

Bowen Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

In vivo formation of Cu(DDC)2 complex induced by nanomedicine for mesothelioma chemotherapy

Yixin Zhang et al.

CHINESE CHEMICAL LETTERS (2020)

Article Chemistry, Multidisciplinary

Highly green fluorescent Nb2C MXene quantum dots for Cu2+ ion sensing and cell imaging

Xiang Yan et al.

CHINESE CHEMICAL LETTERS (2020)

Article Chemistry, Multidisciplinary

Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy

Bolong Xu et al.

ADVANCED MATERIALS (2020)

Review Materials Science, Biomaterials

Recent advances in improving tumor-targeted delivery of imaging nanoprobes

Qianyi Zhang et al.

BIOMATERIALS SCIENCE (2020)

Article Chemistry, Multidisciplinary

Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition

Wencheng Wu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Chemistry, Multidisciplinary

Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities

Lisa Belfiore et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Article Nanoscience & Nanotechnology

Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent

Mohamed Wehbe et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Multidisciplinary Sciences

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Zdenek Skrott et al.

NATURE (2017)

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

Review Oncology

Cancer active targeting by nanoparticles: a comprehensive review of literature

Remon Bazak et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2015)

Article Chemistry, Multidisciplinary

On the interaction of copper(II) with disulfiram

David J. Lewis et al.

CHEMICAL COMMUNICATIONS (2014)

Article Chemistry, Inorganic & Nuclear

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Chun-Yi Sun et al.

DALTON TRANSACTIONS (2012)

Article Biochemistry & Molecular Biology

The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

Pawel Swietach et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Cell Biology

Capturing complex 3D tissue physiology in vitro

LG Griffith et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)