Electrochemical sensor based on a chitosan-molybdenum vanadate nanocomposite for detection of hydroxychloroquine in biological samples

In this study, we firstly introduce an ultra-high sensitive V3.6Mo2.4O16-chitosan (MV-CHT) nanocomposite for electrochemical hydroxychloroquine sulfate (HCQ) monitoring toward paracetamol (PCM) and pantoprazole (PPZ) in environmental and clinical diagnostics. The single-phase MV nanostructures are prepared via the sol-gel pechini route, followed by engineering maleic acid as a structure-directing agent. The stabilization of the MV electro-catalysts is adopted by varying critical factors such as calcination temperature, different chelating ligands, chelating molality and cross-linker concentration. The structural and morphological characterizations, namely, ordered active sites, structural integrity, porous network and dispersibility on the cationic polymer are confirmed by physicochemical analyses. Also, analytical nature of the MV-CHT modified carbon paste electrode (MV-CHT/CPE) is constructed via electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV) techniques. As a result, the nano-MV-CHT/CPE platforms with 10% of polymeric matrixes delivered the boosted analytical performance in terms of linear ranges (0.0019-194.0 mu M), lower detection limit (LOD = 0.224 nM), together with excellent sensitivity and selectivity. The novel combination of MV nanoparticles and CHT provide the fluent channels for rapid charge transport and effective surface area. Such results illustrate the synergistic and interaction capability of MV-CHT-based sensing catalysts with bioactive molecules, which make them as superior drug monitoring devices. (C) 2022 Elsevier Inc. All rights reserved.

Automated summary

In this study, an ultra-high sensitive MV-CHT nanocomposite was introduced for electrochemical monitoring of HCQ. The MV nanostructures were prepared via sol-gel pechini route and stabilized using maleic acid as a structure-directing agent. The MV-CHT modified electrode showed excellent analytical performance with a wide linear range, low detection limit, and high sensitivity and selectivity.