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Is Dose-Adjusted EPOCH-R Less Effective in Children Than Adults With Primary Mediastinal B-Cell Lymphoma?

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Dose-Adjusted Etoposide, Doxorubicin, and Cyclophosphamide With Vincristine and Prednisone Plus Rituximab Therapy in Children and Adolescents With Primary Mediastinal B-Cell Lymphoma: A Multicenter Phase II Trial

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Summary: The dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone plus rituximab (DA-EPOCH-R) regimen did not show improved event-free survival compared to historical controls in children and adolescents with primary mediastinal large B-cell lymphoma (PMLBL) in the first prospective multisite international study, indicating the need for further research to determine the optimal therapy for this lymphoma in young patients.

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