期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 107, 期 7, 页码 E2825-E2832出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgac206
关键词
glycemia; lipidomics; triglycerides; de novo lipogenesis; oral glucose tolerance test; pregnancy; gestational diabetes
资金
- Biotechnology and Biological Sciences Research Council [BB/M027252/1]
- NIHR Cambridge Biomedical Research Centre [IS-BRC-1215-20014]
- Diabetes UK [14/0004849, 17/0005712]
- Tommy's Charity
- European Foundation for the Study of Diabetes-Novo Nordisk Foundation [NNF19SA058974]
- MRC [MC-UU-12012/4]
- National Institute of Health Research [RP-PG-0407-10452]
- Medical Research Council UK [MR/L002477/1]
- Chief Scientist Office, Scottish Government Health Directorates (Edinburgh) [CZB/A/680]
- Biomedical Research Centre at Guys & St Thomas NHS Foundation Trust & King's College London
- NIHR Bristol Biomedical Research Centre, Tommy's Charity, UK [SC039280]
- National Institute for Health Research Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust
- National Institutes of Health Research (NIHR) [RP-PG-0407-10452] Funding Source: National Institutes of Health Research (NIHR)
Gestational diabetes in obese women is associated with elevated levels of specific lipids related to de novo lipogenesis, which are also correlated with measures of offspring adiposity. These findings suggest that the effects of GDM on neonatal body composition may not be solely due to hyperglycemia, but may involve other pathways.
Context Gestational diabetes (GDM) affects 20 million women/year worldwide and is associated with childhood obesity. Infants of affected mothers have increased adiposity from birth, which leads to obesity in later life. However, it remains unknown whether the effect of GDM upon neonatal body composition is due to hyperglycemia alone or is mediated by other pathways. Objective To investigate plasma lipid profiles in obese women according to GDM diagnosis, infant birthweight percentiles, and adiposity. Design Prospective cohort from UPBEAT trial (ISRCTN 89971375). Setting Hospital and community. Patients 867 obese pregnant women recruited in early pregnancy, assessed at 28 weeks for GDM. Offspring anthropometry was assessed at birth. Outcome (Prespecified) Neonatal birth percentile and abdominal circumference. Methods Lipidomic profiling in the fasting plasma oral glucose tolerance test sample using direct infusion mass spectrometry. Analysis included logistic/linear regression, unadjusted and adjusted for maternal age, body mass index, parity, ethnicity, UPBEAT trial arm, and fetal sex. The limit of significance was P = 0.05 for offspring anthropometry and P = 0.002 for lipidomic data. Results GDM in obese women was associated with elevated plasma concentrations of specific diglycerides [DG(32:0)] and triglycerides [TG(48:0), (50:1), (50:2)] containing fatty acids (16:0), (16:1), (18:0), and (18:1), consistent with increased de novo lipogenesis. In the whole cohort, these species were associated with birthweight percentile and neonatal abdominal circumference. Effects upon infant abdominal circumference remained significant after adjustment for maternal glycemia. Conclusions Increased de novo lipogenesis-related species in pregnant women with obesity and GDM are associated with measures of offspring adiposity and may be a target for improving lifelong health.
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