期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 107, 期 7, 页码 E2870-E2881出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgac182
关键词
gut functions; bitter taste; appetite-regulatory hormones; glucoregulatory hormones; gut motility; human
资金
- University of Adelaide
- National Health and Medical Research Council (NHMRC) [1103020, 1158296]
- National Health and Medical Research Council of Australia [1158296] Funding Source: NHMRC
This study investigated the effects of intraduodenal administration of quinine hydrochloride (QHCl) compared to intragastric administration on gut and pancreatic hormones and pyloric pressures in healthy men and women. The results showed that intraduodenal administration of QHCl had greater effects on the release of gut and pancreatic hormones and pyloric pressures compared to intragastric administration. The study also found that insulin stimulation and glucose lowering were more pronounced in females, while other hormones and pressures were not affected by sex.
Context The bitter substance quinine modulates the release of a number of gut and gluco-regulatory hormones and upper gut motility. As the density of bitter receptors may be higher in the duodenum than the stomach, direct delivery to the duodenum may be more potent in stimulating these functions. The gastrointestinal responses to bitter compounds may also be modified by sex. Background We have characterized the effects of intragastric (IG) versus intraduodenal (ID) administration of quinine hydrochloride (QHCl) on gut and pancreatic hormones and antropyloroduodenal pressures in healthy men and women. Methods 14 men (26 +/- 2 years, BMI: 22.2 +/- 0.5 kg/m(2)) and 14 women (28 +/- 2 years, BMI: 22.5 +/- 0.5 kg/m(2)) received 600 mg QHCl on 2 separate occasions, IG or ID as a 10-mL bolus, in randomized, double-blind fashion. Plasma ghrelin, cholecystokinin, peptide YY, glucagon-like peptide-1 (GLP-1), insulin, glucagon, and glucose concentrations and antropyloroduodenal pressures were measured at baseline and for 120 minutes following QHCl. Results Suppression of ghrelin (P = 0.006), stimulation of cholecystokinin (P = 0.030), peptide YY (P = 0.017), GLP-1 (P = 0.034), insulin (P = 0.024), glucagon (P = 0.030), and pyloric pressures (P = 0.050), and lowering of glucose (P = 0.001) were greater after ID-QHCl than IG-QHCl. Insulin stimulation (P = 0.021) and glucose reduction (P = 0.001) were greater in females than males, while no sex-associated effects were found for cholecystokinin, peptide YY, GLP-1, glucagon, or pyloric pressures. Conclusion ID quinine has greater effects on plasma gut and pancreatic hormones and pyloric pressures than IG quinine in healthy subjects, consistent with the concept that stimulation of small intestinal bitter receptors is critical to these responses. Both insulin stimulation and glucose lowering were sex-dependent.
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