4.7 Article

Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults

期刊

出版社

MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2015.06.017

关键词

Rhinovirus; acute respiratory illness; adults; hospitalized; emergency department; smoking

资金

  1. Clinical and Translational Science Award [5UL1 RR024975-03]
  2. Vanderbilt-Ingram Cancer Center [P30 CA68485]
  3. Vanderbilt Vision Center [P30 EY08126]
  4. National Institutes of Health (NIH)/National Center for Research Resources [G20 RR030956]
  5. National Center for Advancing Translational Sciences (NCATS)/NIH [UL1 TR000445]
  6. NIH/National Institute of Allergy and Infectious Diseases [AI101629]
  7. Centers for Disease Control and Prevention (CDC) [U18 1P000184]

向作者/读者索取更多资源

Background: Rhinovirus is linked to asthma exacerbations and chronic obstructive pulmonary disease exacerbations in adults. The severity and rates of rhinovirus acute respiratory illnesses (ARIs) in adults are uncertain. Objectives: We sought to determine rhinovirus-associated ARI rates in adults presenting for care in multiple settings and identify factors associated with rhinovirus detection. Methods: This prospective, population-based cohort enrolled Tennessee residents 18 years or older in the emergency department (ED), outpatient clinics, or hospitalized for ARI from December 2008 to May 2010. Nasal/throat swabs were collected and tested for rhinovirus and other viruses by using RT-PCR. Rates of ED visits and hospitalizations were calculated and rhinovirus-positive and rhinovirus-negative patients were compared. Results: Among 2351 enrollees, rhinovirus was detected in 247 (11%). There were 7 rhinovirus-associated ED visits and 3 hospitalizations per 1000 adults annually. Patients with rhinovirus, compared with virus-negative ARI, were more likely to present with wheezing (odds ratio [OR], 1.7; 95% CI, 1.23-2.35; P < .001), to be a current smoker (OR, 2.31; 95% CI, 1.68-3.19) or live with a smoker (OR, 1.72; 95% CI, 1.10-2.67), have a history of chronic respiratory disease (OR, 1.61; 95% CI, 1.17-2.22), and were less likely to be hospitalized versus seen in the outpatient setting (OR, 0.58; 95% CI, 0.41-0.83). Conclusions: Rhinovirus is associated with a substantial number of ED visits and hospitalizations for ARIs in adults. There may be modifiable factors that can reduce the likelihood of presenting with rhinovirus-associated ARIs.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据