期刊
出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2022.123202
关键词
Mescaline; Hallucinogen; Illicit drug; Ultra -high performance liquid; chromatography -tandem mass spectrometry; Hair analysis
资金
- National Natural Science Foundation of China [81971789, 81872833]
- Shanghai Key Laboratory of Forensic Medicine [21DZ2270800]
- Shanghai Forensic Service Platform [19DZ2292700]
- [GY2021G-6]
Mescaline, a natural alkaloid found in the peyote cactus, has become a drug of abuse in China. This study developed a rapid and accurate method to determine and quantify mescaline in hair, suitable for large-scale surveillance analysis.
Mescaline, a natural alkaloid found in the peyote cactus (Lophophora williamsii) in the Americas, has gradually become a drug of abuse in China because of its psychedelic properties. Its intake may lead to hallucinations and confusion or even be life-threatening. Mescaline is classified as a class I psychotropic drug in China, which means its use in medicine or scientific research is under strict control of the government. However, studies on sur-veillance of mescaline abuse in the Chinese population are lacking. A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination and quantification of mescaline in hair. The method had good linearity in the range from 10 to 1000 pg/mg, with the limit of detection (LOD) of 3 pg/mg and the limit of quantitation (LOQ) of 10 pg/mg. The total runtime was 5 min. Acceptable intraday and interday precision (RSD < 15%) and ac-curacy (bias,-11.2% ~ 6.8%) were achieved. The recovery was 85.0-101.0%, and the matrix effect was 92.0-105.0%. The validated method was successfully applied to 19 real forensic cases. The concentrations of mescaline in hair ranged from 10 to 784 pg/mg. The method has the benefits of simple sample preparation, high sensitivity, and short running time, making it suitable for large-scale quantitative surveillance analysis of mescaline in forensic toxicology.
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