期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1667, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2022.462912
关键词
Stationary phase; HPLC; Mixed-mode; Hydrophilic-hydrophobic; Acid-base balance
资金
- National Key Research and Development Program of China [2019YFD1002403]
- National Natural Science Foundation of China [22074154, 21822407]
- Youth Innovation Promotion Association CAS [2021420]
- Foundation for Sci&Tech Research Project of Gansu Province [20JR10RA052, 20JR5RA573]
Two new hydrophilic-hydrophobic and acid-base balanced liquid chromatographic stationary phases were developed using polymer-functionalized silica design strategy. These stationary phases can separate compounds with different properties in reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography modes.
Two new hydrophilic-hydrophobic and acid-base balanced liquid chromatographic stationary phases were obtained by using two long-chain monomers including undecylenic acid (UA) and oleic acid (OA) combined with short-chain 4-vinyl pyridine (Py) in-situ polymerized on silica microspheres surfaces, respectively. These two stationary phases can be used for reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC) modes. Hydrophilic, hydrophobic, acidic and basic analytes can be separated on two new stationary phases in RPLC or HILIC mode. Compared with commercial hydrophobic C18 columns and other HILIC columns, two new stationary phases have excellent selectivity and separation performance in the separation of 9 polycyclic aromatic hydrocarbons, 10 aromatic acids, 10 anilines and 5 oxazolidinones, respectively. This novel polymer-functionalized silica design strategy has opened up new ideas for the future of mixed-mode stationary phases with multiple functions and specificity. (c) 2022 Elsevier B.V. All rights reserved.
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