期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1670, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.chroma.2022.462970
关键词
Generalized Dispersion Theory (GDT); Liquid chromatography; Vortex; Acoustofluidics
资金
- European Research Council [679033EVODIS ERC-2015-STG]
- Research Foundation - Flanders (FWO) [1512018N]
- VLAIO [HBC.2020.2627]
- Catalisti [HBC.2020.2627]
Acoustically induced secondary flows can enhance lateral mass transfer to improve the performance of column chromatography. The generalized dispersion theory (GDT) can predict the improvement based on the characteristics of the induced secondary flow, channel geometry, and solute properties. Experimental results show agreement with the application of GDT.
Acoustically induced secondary flows are applied to enhance lateral mass transfer beyond the relatively slow diffusion. This has the goal to reduce convective axial dispersion and the resulting band broadening which, in turn, limits the performance of column chromatography. Traditional approaches based on Taylor-Aris model are limited to one-dimensional rectilinear (unidirectional) tube-or channel-flows. We therefore apply the generalized dispersion theory (GDT) allowing for prediction of the dependence of potentially improved performance on the characteristics of the induced secondary flow, channel geometry and solute properties as well as providing qualitative physical insight into the role of lateral flows. Results corroborate agreement with our experimental observations (residual standard deviation, S-res = 3.88) and demonstrate the advantage of applying GDT relative to 3D time-dependent simulations. (C) 2022 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据