期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 42, 期 8, 页码 1493-1506出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X221083471
关键词
Arterial spin labeling; arterial transit time; cerebral blood flow; cerebrovascular reactivity; Moyamoya disease
资金
- American Heart Association [826254]
- National Institutes of Health [R01EB025220-02, 4R00NS102884-03, 1K99-AG068310-01A1]
This study investigates the effectiveness of ASL with single and multiple PLD for CVR and transit time mapping in Moyamoya patients. Results show that multi-PLD ASL has a high agreement with PET and can accurately measure transit time.
Cerebrovascular reactivity (CVR) reflects the CBF change to meet different physiological demands. The reference CVR technique is PET imaging with vasodilators but is inaccessible to most patients. DSC can measure transit time to evaluate patients suspected of stroke, but the use of gadolinium may cause side-effects. Arterial spin labeling (ASL) is a non-invasive MRI technique for CBF measurements. Here, we investigate the effectiveness of ASL with single and multiple post labeling delays (PLD) to replace PET and DSC for CVR and transit time mapping in 26 Moyamoya patients. Images were collected using simultaneous PET/MRI with acetazolamide. CVR, CBF, arterial transit time (ATT), and time-to-maximum (Tmax) were measured in different flow territories. Results showed that CVR was lower in occluded regions than normal regions (by 68 +/- 12%, 52 +/- 5%, and 56 +/- 9%, for PET, single- and multi-PLD PCASL, respectively, all p < 0.05). Multi-PLD PCASL correlated slightly higher with PET (CCC = 0.36 and 0.32 in affected and unaffected territories respectively). Vasodilation caused ATT to reduce by 4.5 +/- 3.1% (p < 0.01) in occluded regions. ATT correlated significantly with Tmax (R-2 > 0.35, p < 0.01). Therefore, multi-PLD ASL is recommended for CVR studies due to its high agreement with the reference PET technique and the capability of measuring transit time.
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