期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 237, 期 7, 页码 2961-2968出版社
WILEY
DOI: 10.1002/jcp.30761
关键词
Arabidopsis thaliana; epigenetic; flowering; HDA9; histone deacetylase; HY5
资金
- Guangdong Natural Science Funds for Distinguished Young Scholars [2022B1515020026]
- Youth Innovation Promotion Association, Chinese Academy of Sciences [Y2021094]
- KeyAreas Research and Development Program of Guangdong Province [2020B020220004]
- National Natural Science Foundation of China [32170362]
- Science and Technology Program of Guangzhou [202002030097]
HDA9 and HY5 repress the expression of PIF4 and COL5 through H3K9 and H3K27 deacetylation, thereby controlling flowering time in plants.
Histone deacetylases (HDACs) play important roles in the repression of gene expression. Our previous study revealed that HISTONE DEACETYLASE 9 (HDA9) interacts with ELONGATED HYPOCOTYL 5 (HY5) and is involved in regulating plant autophagy in response to the light-to-dark transition and nitrogen starvation. In this study, we observed that the hda9-1 and hy5-215 single mutants flowered earlier compared with the wild-type Col-0; in addition, the hda9-1 hy5-215 double mutant flowered earlier than each single mutant. The expression of several positive flowering time genes was upregulated in the hda9-1, hy5-215, and hda9-1 hy5-215 mutants. Chromatin immunoprecipitation analysis demonstrated that HDA9 and HY5 bound directly to the promoter regions of PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) and CONSTANS-LIKE 5 (COL5) and repressed their expression through H3K9 and H3K27 deacetylation. Taken together, our results reveal the epigenetic mechanism explaining how the HDA9-HY5 module functions in controlling flowering time.
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