期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 26, 期 13, 页码 3591-3597出版社
WILEY
DOI: 10.1111/jcmm.17399
关键词
osteoimmunology; Th17; Treg; RANKL; osteoclasts; osteoporosis
资金
- Innovation Fund of the Third Affiliated Hospital of Guangzhou University of Chinese Medicine [sy2018012]
- Scientific Research Project of Traditional Chinese Medicine Bureau of Guangdong Province [20201170]
Osteoporosis, a bone disease with a high disability rate, has been a hot topic in bone biology research. Previous understanding of osteoporosis was limited, but recent studies have shown the correlation between the skeletal and immune systems. Investigating the roles of RANKL and the Th17/Treg balance can provide new insights for the treatment of osteoporosis.
Osteoporosis is a bone disease that is caused by disorder of the skeletal microenvironment, and it characterized by a high disability rate and the occurrence of low energy fractures. Studies on osteoporosis and related treatment options have always been hot spots in the field of bone biology. In the past, the understanding of osteoporosis has been rather limited; research has only shown that osteoporosis involves the imbalance of bone resorption and bone formation, and recent studies have not provided cutting-edge theories of the basic understanding of osteoporosis. Recent studies have shown crosstalk between bone and immune responses. RANKL, an essential factor for osteoclasts (OCs), is associated with the immune system. T helper (Th17)/regulatory T (Treg) cells are two different kinds of T cells that can self-interact and regulate the differentiation and formation of OCs. Therefore, understanding the correlation between the skeletal and immune systems and further revealing the roles and the cooperation between RANKL and the Th17/Treg balance will help to provide new insights for the treatment of osteoporosis.
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