期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 26, 期 9, 页码 2706-2716出版社
WILEY
DOI: 10.1111/jcmm.17283
关键词
Antrodia Camphorata Polysaccharide; Kupffer cells; liver injury; NLRP3; Nrf2 signal
资金
- ZheJiang provincial Natural Science Foundation [LYY20H280005]
This study suggests that Antrodia Camphorata Polysaccharide (ACP) can protect the liver by inhibiting the production of reactive oxygen species (ROS) and activating the Nrf2 signal pathway, thereby reducing inflammation and improving liver injury.
Antrodia Camphorata Polysaccharide (ACP) refers to a kind of polysaccharide extracted from the natural porous fungus Antrodia camphorata. This study investigated the mechanism of action of ACP in protecting the liver. The results showed that ACP suppressed the LPS-induced KC cell activation, reduced the expression of inflammatory factors, increased the SOD level and suppressed ROS expression. In addition, N-acetylcysteine (NAC) was adopted for pre-treatment to suppress ROS. The results indicated that NAC synergistically exerted its effect with ACP, suggesting that ACP played its role through suppressing ROS. Further detection revealed that ACP activated the Nrf2 signal. It was discovered in the mouse model that, ACP effectively improved liver injury in mice, decreased ALT and AST levels, and suppressed the expression of inflammatory factors. This study suggests that ACP can exert its effect against oxidative stress via the Nrf2-ARE signalling, which further improves the production of ROS and the activation of TLR4-NF-kappa B signalling, and protects the liver against liver injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据