Bifunctional ligand enabled selective alkoxycarbonylation of aliphatic alkenes

Carbazole derived phosphine ligands containing pyridine moiety were designed and prepared. It allows the challenging Pd-catalyzed Markovnikov-selective alkoxycarbonylation of aliphatic alkenes to give the branched ester products (28 examples; 51-97% branch selectivity). Preliminary mechanistic studies sup-port that the bridging bromide between Pd and Mn centers is crucial for the enhancement of regioselectivity. (c) 2022 Elsevier Inc. All rights reserved.

Automated summary

In this study, carbazole derived phosphine ligands containing a pyridine moiety were designed and prepared to enable the Pd-catalyzed Markovnikov-selective alkoxycarbonylation of aliphatic alkenes, yielding branched ester products. Preliminary mechanistic studies suggest that the bridging bromide between Pd and Mn centers is crucial for enhancing regioselectivity.