4.5 Review

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

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Hongcai Yang et al.

Summary: Polyurethane (PU) NGCs modified by different weight ratio of Gastrodin were designed for sequential and sustainable drug release, creating a favorable microenvironment for nerve regeneration. The scaffold showed suitable pore structure and biocompatibility in vitro, and promoted morphological and functional recovery of regenerated sciatic nerves in vivo.

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Summary: The study found that the use of polyurethane scaffolds in meniscal substitution can maintain normal T2 mapping values in adjacent cartilage at 12 months post-operation. Adding MSC did not show any significant advantage in protecting articular cartilage over acellular scaffolds.

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Aldin Malkoc et al.

Summary: This case series describes the treatment course of patients with greater than 90% TBSA full-thickness burn injuries using a staged, multifaceted approach of using NovoSorb Biodegradable Temporizing Matrix (TM) as the primary dermal substitute in conjunction with a RECELL (TM) Autologous Cell Suspensions Device applied with autograft and allograft to achieve improved resuscitation, limiting fluid loss, and finally skin coverage.

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Emanuela S. Fioretta et al.

Summary: Valvular heart disease is a significant cause of morbidity and mortality worldwide, but current clinically adopted heart valve replacement options have limitations. Next-generation tissue-engineered heart valves have the potential to address these limitations and become a promising therapeutic alternative for patients with valvular disease.

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Covalent grafting of PEG and heparin improves biological performance of electrospun vascular grafts for carotid artery replacement

Tonghe Zhu et al.

Summary: The study synthesized PEUU@PEG-Hep vascular graft with good biocompatibility and blood compatibility, and the covalent grafting of PEG and heparin significantly enhanced endothelial cell adhesion, spreading, and proliferation, as well as improved the grafts' ability to prevent platelet deposition.

ACTA BIOMATERIALIA (2021)

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Giulia Battafarano et al.

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A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament in a Rat Model

Yohei Kawakami et al.

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ACTA BIOMATERIALIA (2021)

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Anamika Singh et al.

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Bahram Mirani et al.

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BIOACTIVE MATERIALS (2021)

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Wenying Wei et al.

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Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

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Synthesis and characterization of a novel biodegradable antimicrobial polymer

GLY Woo et al.

BIOMATERIALS (2000)