4.6 Article

A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies

Stephan T. Kudlacek et al.

Summary: By utilizing molecular modeling, researchers identified mutations in the DENV2 E protein that induce dimerization at low concentrations and enhance production yield. Antibodies targeting the stabilized dimers were found to elicit higher levels of DENV2-neutralizing antibodies compared to antibodies targeting WT E antigen. These findings demonstrate the potential of structure-based design for producing subunit vaccines for dengue and other flaviviruses.

SCIENCE ADVANCES (2021)

Review Virology

Mapping the diverse structural landscape of the flavivirus antibody repertoire

Madhumati Sevvana et al.

CURRENT OPINION IN VIROLOGY (2020)

Article Medicine, Research & Experimental

Human antibody response to Zika targets type-specific quaternary structure epitopes

Matthew H. Collins et al.

JCI INSIGHT (2019)

Article Biochemistry & Molecular Biology

Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins

Stephan T. Kudlacek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Quantitative mass imaging of single biological macromolecules

Gavin Young et al.

SCIENCE (2018)

Review Biochemistry & Molecular Biology

The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design

Felix A. Rey et al.

EMBO REPORTS (2018)

Article Multidisciplinary Sciences

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

Alexander Rouvinski et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Structural basis of potent Zika-dengue virus antibody cross-neutralization

Giovanna Barba-Spaeth et al.

NATURE (2016)

Article Multidisciplinary Sciences

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

Alexander Rouvinski et al.

NATURE (2015)

Article Medicine, General & Internal

Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease

S. R. Hadinegoro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Microbiology

Receptors and routes of dengue virus entry into the host cells

Christine Cruz-Oliveira et al.

FEMS MICROBIOLOGY REVIEWS (2015)

Article Multidisciplinary Sciences

The global distribution and burden of dengue

Samir Bhatt et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Cryo-EM structure of the mature dengue virus at 3.5-angstrom resolution

Xiaokang Zhang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

Ruklanthi de Alwis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Virology

The Human Antibody Response to Dengue Virus Infection

Wahala M. P. B. Wahala et al.

VIRUSES-BASEL (2011)

Article Multidisciplinary Sciences

Structure of the dengue virus envelope protein after membrane fusion

Y Modis et al.

NATURE (2004)