Schisanwilsonins H and I, two new dibenzocyclooctane lignans from the fruits of Schisandra wilsoniana

Two new dibenzocyclooctane lignans, schisanwilsonins H (1) and I (2), together with eight known compounds gomisin J (3), wulignan A(1) (4), gomisin S (5), tigloylgomisin P (6), gomisin O (7), (-)-gomisin K-1 (8), rubschisantherin (9) and wuweizisu C (10) were isolated from the 95% ethanol extract of the fruits of Schisandra wilsoniana. 7 exhibited anti-HBV activity with potency against HBsAg and HBeAg secretion by 37.1% and 32.6%, respectively, at 50 mu g/ml. 10 exhibited anti-HIV activity with EC50 and therapeutic index (TI) values of 2.10 mu g/ml and 11.98, respectively.

Automated summary

Two new dibenzocyclooctane lignans, schisanwilsonins H (1) and I (2), along with eight known compounds, were isolated from the 95% ethanol extract of Schisandra wilsoniana fruits. Compound 7 exhibited anti-HBV activity, while compound 10 showed anti-HIV activity.