期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 25, 期 2, 页码 147-155出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2022.2075738
关键词
Trichocomaceae; Talaromyces amestolkiae; phthalide; absolute configuration; anti-neuroinflammation
Amestolkins A and B, two previously undescribed phthalides, were isolated from Talaromyces amestolkiae. They exhibited anti-neuroinflammatory activity by inhibiting the gene expressions of proinflammatory factors and attenuating the excretion of inducible nitric oxide synthase in BV-2 microglial cells.
Amestolkins A (1) and B (2), two previously undescribed phthalides sharing the same planar structure of (1, 5-dihydroxyhexyl)-7-hydroxyisobenzofuran-1(3H)-one were isolated from Talaromyces amestolkiae. Their absolute configurations were elucidated by comprehensive analyses of spectroscopic evidences in high-resolution electrospray mass spectra (HRESIMS) and nuclear magnetic resonance (NMR) combined with electronic circular dichroism (ECD) and NMR calculations. 1 and 2 showed anti-neuroinflammatory activity by inhibiting the gene expressions of proinflammatory factors including C-C motif chemokine ligand 2 (CCL-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), as well as attenuating the excretion of inducible nitric oxide synthase (iNOS) in BV-2 microglial cells at the concentration of 30 mu M.
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