期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 90, 期 3, 页码 989-992出版社
IOS PRESS
DOI: 10.3233/JAD-215647
关键词
Alzheimer's disease; dementia; health inequities; multidomain interventions; public health; risk reduction; social determinants of health
资金
- Fondation Mederic Alzheimer
- National Scientific and Technical Research Council (CONICET)
- foundations France Alzheimer
- Fondation Recherche Alzheimer
- Philippe Chatrier
- Rosita Gomez association
Although non-pharmacological risk reduction is seen as an alternative to targeting Alzheimer's disease pathology, over-reliance on multi-domain interventions may have limited individual impact, focus solely on later life, and overlook social determinants of dementia. Therefore, a broader debate within the research community and society about exploring different therapeutic avenues is necessary.
Given the unknown therapeutic value of targeting Alzheimer's disease pathology and the discovery of robust risk factors for dementia, non-pharmacological risk reduction (RR) is increasingly offered as an alternative to targeting Alzheimer's disease pathology. While RR will surely be a useful tool to make public health gains, we propose solutions to three possible issues with over-reliance on multi-domain interventions to achieve RR: limited individual impact, an exclusive focus on later life, and overlooking social determinants of dementia. We argue in favor of a broader debate within the research community and greater society about how different therapeutic avenues should be explored.
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