Avoiding Over-Reliance on Multi-Domain Interventions for Dementia Prevention Comment

Given the unknown therapeutic value of targeting Alzheimer's disease pathology and the discovery of robust risk factors for dementia, non-pharmacological risk reduction (RR) is increasingly offered as an alternative to targeting Alzheimer's disease pathology. While RR will surely be a useful tool to make public health gains, we propose solutions to three possible issues with over-reliance on multi-domain interventions to achieve RR: limited individual impact, an exclusive focus on later life, and overlooking social determinants of dementia. We argue in favor of a broader debate within the research community and greater society about how different therapeutic avenues should be explored.

Automated summary

Although non-pharmacological risk reduction is seen as an alternative to targeting Alzheimer's disease pathology, over-reliance on multi-domain interventions may have limited individual impact, focus solely on later life, and overlook social determinants of dementia. Therefore, a broader debate within the research community and society about exploring different therapeutic avenues is necessary.