期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 87, 期 3, 页码 1079-1087出版社
IOS PRESS
DOI: 10.3233/JAD-215736
关键词
Cognition; cognitive; lutein; macular pigment; meso-zeaxanthin; zeaxanthin
资金
- Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) [1D57HP40200-01-00]
Studies have shown that macular pigments are positively correlated with cognitive function and macular pigment optical density is related to cognitive performance in adults. Higher levels of macular pigments in the blood are associated with a lower risk of mild cognitive impairments or Alzheimer's disease. Diet supplements of Lutein+Zeaxanthin or Lutein+Zeaxanthin+Meso-zeaxanthin are associated with improved cognitive functioning in adults.
Background: Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are collectively called macular pigment. MZ can be converted from L in the macula. In the recent decade, many studies have been performed to investigate the effects for taking carotenoids, especially L and Z or L, Z, and MZ, as diet supplements on human health. Objective: We examined if diet supplements of L+ Z or L+ Z+ MZ have effects on cognitive function in adults. Methods: A systemic literature search was performed in March 2021 with the following keywords: lutein, zeaxanthin, meso-zeaxanthin, cognition, cognitive, and macular pigment. The searched databases included Medline EBSCOhost, Scopus, Elsevier, Cochrane Library, ProQuest, and ClinicalTrials.gov. Findings from eight clinical trials were presented as the strongest evidence on the studied topic. Results: Most studies have found that macular pigments (L + Z) in blood or macula are positively correlated with cognitive performance. As an index of the amount of macular pigments in the brain, macular pigment optical density is related to cognitive performance in adults. In addition, there is an inverse relationship between a higher amount of macular pigment in the blood and lower risk of mild cognitive impairments or Alzheimer's disease. Based on the findings from the clinical trials, diet supplements of L+ Z or L+ Z+ MZ are associated with improved cognition in adults. Conclusion: The diet supplements of L+ Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据