4.5 Review

Combination Therapy in Alzheimer's Disease: Is It Time?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Dentistry, Oral Surgery & Medicine

Periodontal bacteria in the brain-Implication for Alzheimer's disease: A systematic review

Valeria Parra-Torres et al.

Summary: Periodontitis is a chronic non-communicable disease caused by a dysbiotic microbiota. Pathogens can spread to the brain, induce an immune response, and lead to the development of Alzheimer's disease (AD). Studies have found oral bacteria in the brains of animals and AD patients, suggesting a potential oral-brain axis in the etiology of AD.

ORAL DISEASES (2023)

Article Nanoscience & Nanotechnology

Oral Administration of Resveratrol-Selenium-Peptide Nanocomposites Alleviates Alzheimer's Disease-like Pathogenesis by Inhibiting Aβ Aggregation and Regulating Gut Microbiota

Changjiang Li et al.

Summary: A Res-selenium-peptide nanocomposite was developed to improve cognitive dysfunction in AD model mice by reducing Aβ aggregation, inhibiting Aβ deposition, decreasing oxidative stress and inflammation, and alleviating gut microbiota disorder.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Environmental Sciences

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer's Disease: A Systematic Review

Yoann Maitre et al.

Summary: This review systematically examines the link between the oral microbiome and Alzheimer's disease, highlighting the impact of the oral microbiome on pathophysiological and immunoinflammatory mechanisms. The review also proposes potential therapeutic perspectives involving phototherapy and the use of prebiotic compounds and probiotic strains for modulating the oral microbiome and influencing the progression of the disease.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Clinical Neurology

Can we learn lessons from the FDA's approval of aducanumab?

Kathy Y. Liu et al.

Summary: The FDA recently granted accelerated approval to aducanumab for the treatment of Alzheimer disease. Here, the authors reflect on the events that led to this controversial approval and consider whether any lessons can be learned for the field.

NATURE REVIEWS NEUROLOGY (2021)

Editorial Material Medicine, General & Internal

Revisiting FDA Approval of Aducanumab

G. Caleb Alexander et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Biochemistry & Molecular Biology

Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype

Virginie Lam et al.

Summary: The study showed that in mice engineered to synthesize human Ass only in the liver, there was marked neurodegeneration, capillary dysfunction, parenchymal extravasation of lipoprotein-Ass, and neurovascular inflammation. These findings suggest a potential association between a lipoprotein-Ass/capillary axis and the onset and progression of neurodegenerative diseases.

PLOS BIOLOGY (2021)

Review Pharmacology & Pharmacy

Oral microbiota and Alzheimer's disease: Do all roads lead to Rome?

Antoni Sureda et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Neurosciences

Synergy between amyloid-β and tau in Alzheimer's disease

Marc Aurel Busche et al.

NATURE NEUROSCIENCE (2020)

Review Clinical Neurology

Invite Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials

D. Boche et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

Article Biochemical Research Methods

Artificial intelligence in drug combination therapy

Igor F. Tsigelny

BRIEFINGS IN BIOINFORMATICS (2019)

Article Physiology

Dynamic Targeting in Cancer Treatment

Zhihui Wang et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Biology

Modeling HIV Dynamics Under Combination Therapy with Inducers and Antibodies

Chao Yan et al.

BULLETIN OF MATHEMATICAL BIOLOGY (2019)

Review Nanoscience & Nanotechnology

Alzheimer's disease: pathogenesis, diagnostics, and therapeutics

Sneham Tiwari et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Radiology, Nuclear Medicine & Medical Imaging

Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease

Delphine Boche et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

Review Neurosciences

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options

Jeffrey L. Cummings et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Neurosciences

Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo

Marc Aurel Busche et al.

NATURE NEUROSCIENCE (2019)

Review Gastroenterology & Hepatology

Brain-Gut-Microbiota Axis in Alzheimer's Disease

Karol Kowalski et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2019)

Review Pharmacology & Pharmacy

Molecular targeted therapy: Treating cancer with specificity

Yeuan Ting Lee et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Near-atomic model of microtubule-tau interactions

Elizabeth H. Kellogg et al.

SCIENCE (2018)

Article Geriatrics & Gerontology

Alzheimer Disease

John E. Morley et al.

CLINICS IN GERIATRIC MEDICINE (2018)

Article Multidisciplinary Sciences

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Pilar Mendoza et al.

NATURE (2018)

Review Geriatrics & Gerontology

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer's Disease?

Tamas Fulop et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Neurosciences

New insights into the role of TREM2 in Alzheimer's disease

Maud Gratuze et al.

MOLECULAR NEURODEGENERATION (2018)

Review Peripheral Vascular Disease

Triple-combination therapy in the treatment of hypertension: a review of the evidence

R. Duesing et al.

JOURNAL OF HUMAN HYPERTENSION (2017)

Editorial Material Biotechnology & Applied Microbiology

Combination products: modernizing the regulatory paradigm

Nina L. Hunter et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Review Medicine, General & Internal

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

Janet Woodcock et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

A beta-amyloid and Tau Imaging in Dementia

Victor L. Villemagne et al.

SEMINARS IN NUCLEAR MEDICINE (2017)

Review Geriatrics & Gerontology

Exploring the Association between Alzheimer's Disease, Oral Health, Microbial Endocrinology and Nutrition

Alice Harding et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Article Clinical Neurology

Metabolic network failures in Alzheimer's disease: A biochemical road map

Jon B. Toledo et al.

ALZHEIMERS & DEMENTIA (2017)

Article Mathematical & Computational Biology

Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model

Xiulan Lai et al.

BMC SYSTEMS BIOLOGY (2017)

Review Cell Biology

Drug candidates in clinical trials for Alzheimer's disease

Shih-Ya Hung et al.

JOURNAL OF BIOMEDICAL SCIENCE (2017)

Article Pathology

Enhanced Tau Aggregation in the Presence of Amyloid β

Rachel E. Bennett et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

Article Clinical Neurology

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

Randall J. Bateman et al.

ALZHEIMERS & DEMENTIA (2017)

Review Geriatrics & Gerontology

Inflammaging decreases adaptive and innate immune responses in mice and humans

Daniela Frasca et al.

BIOGERONTOLOGY (2016)

Article Clinical Neurology

Challenges, solutions, and recommendations for Alzheimer's disease combination therapy

James A. Hendrix et al.

ALZHEIMERS & DEMENTIA (2016)

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Immunology

Microglial immunophenotype in dementia with Alzheimer's pathology

Thais Minett et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

LANCET (2016)

Article Endocrinology & Metabolism

Role of metabolism in neurodegenerative disorders

Claudio Procaccini et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Multidisciplinary Sciences

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

Johannes F. Scheid et al.

NATURE (2016)

Review Nutrition & Dietetics

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Francesca Pistollato et al.

NUTRITION REVIEWS (2016)

Review Pharmacology & Pharmacy

Therapeutic strategies for Alzheimer's disease in clinical trials

Justyna Godyn et al.

PHARMACOLOGICAL REPORTS (2016)

Article Critical Care Medicine

Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis

Annie Christine Lajoie et al.

LANCET RESPIRATORY MEDICINE (2016)

Article Neurosciences

Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

Milos D. Ikonomovic et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Clinical Neurology

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

Osama Sabri et al.

ALZHEIMERS & DEMENTIA (2015)

Review Microbiology

Antibiotics, Pediatric Dysbiosis, and Disease

Pajau Vangay et al.

CELL HOST & MICROBE (2015)

Review Pharmacology & Pharmacy

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

Anastasia I. Petra et al.

CLINICAL THERAPEUTICS (2015)

Article Geriatrics & Gerontology

Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease

Vincenzina Nicolia et al.

EXPERIMENTAL GERONTOLOGY (2015)

Review Pharmacology & Pharmacy

The optimal combination therapy for the treatment of early rheumatoid arthritis

Diederik De Cock et al.

EXPERT OPINION ON PHARMACOTHERAPY (2015)

Review Clinical Neurology

Building a roadmap for developing combination therapies for Alzheimer's disease

Daniel Perry et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Review Clinical Neurology

Clearance systems in the brain-implications for Alzheimer disease

Jenna M. Tarasoff-Conway et al.

NATURE REVIEWS NEUROLOGY (2015)

Review Neurosciences

Immune attack: the role of inflammation in Alzheimer disease

Frank L. Heppner et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Review Clinical Neurology

Building a roadmap for developing combination therapies for Alzheimer's disease

Daniel Perry et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Review Clinical Neurology

Charting a path toward combination therapy for Alzheimer's disease

Diane Stephenson et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Review Clinical Neurology

Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols

Stefania Rigacci et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)

Article Geriatrics & Gerontology

Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals

V. Berti et al.

JOURNAL OF NUTRITION HEALTH & AGING (2015)

Article Neurosciences

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Robert P. Friedland

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Clinical Neurology

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Sergio T. Ferreira et al.

ALZHEIMERS & DEMENTIA (2014)

Review Pharmacology & Pharmacy

Brain metabolic dysfunction at the core of Alzheimer's disease

Suzanne M. de la Monte et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Article Medicine, General & Internal

Pathways to Alzheimer's disease

J. Hardy et al.

JOURNAL OF INTERNAL MEDICINE (2014)

Review Immunology

Tracking neuroinflammation in Alzheimer's disease: the role of positron emission tomography imaging

Eduardo Rigon Zimmer et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Review Food Science & Technology

Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases

Francesca Pistollato et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2014)

Article Clinical Neurology

Alzheimer's disease drug-development pipeline: few candidates, frequent failures

Jeffrey L. Cummings et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

Review Microbiology

Fold modulating function: bacterial toxins to functional annyloids

Adnan K. Syed et al.

FRONTIERS IN MICROBIOLOGY (2014)

Review Geriatrics & Gerontology

The genetics of Alzheimer's disease

Eva Bagyinszky et al.

CLINICAL INTERVENTIONS IN AGING (2014)

Article Clinical Neurology

Much of Late Life Cognitive Decline Is Not due to Common Neurodegenerative Pathologies

Patricia A. Boyle et al.

ANNALS OF NEUROLOGY (2013)

Review Chemistry, Medicinal

The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

M. Carmo Carreiras et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

Article Immunology

The intricate association between gut microbiota and development of Type 1, Type 2 and Type 3 diabetes

Pjotr Bekkering et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2013)

Review Neurosciences

What causes Alzheimer's disease?

Richard A. Armstrong

FOLIA NEUROPATHOLOGICA (2013)

Review Neurosciences

Food, Nutrigenomics, and Neurodegeneration-Neuroprotection by What You Eat!

Ashraf Virmani et al.

MOLECULAR NEUROBIOLOGY (2013)

Editorial Material Multidisciplinary Sciences

CANCER Calculated treatment

Natalia L. Komarova et al.

NATURE (2013)

Article Geriatrics & Gerontology

Neuroinflammatory phenotype in early Alzheimer's disease

Tiffany L. Sudduth et al.

NEUROBIOLOGY OF AGING (2013)

Review Pharmacology & Pharmacy

The influence of diet on the gut microbiota

Karen P. Scott et al.

PHARMACOLOGICAL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Alzheimer disease A tale of two prions

Justin M. Nussbaum et al.

Article Nutrition & Dietetics

Potential benefits of adherence to the Mediterranean diet on cognitive health

Catherine Feart et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2013)

Article Clinical Neurology

Alzheimer's Disease

Carly Oboudiyat et al.

SEMINARS IN NEUROLOGY (2013)

Article Multidisciplinary Sciences

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

Vinita Rangroo Thrane et al.

SCIENTIFIC REPORTS (2013)

Review Behavioral Sciences

Inflammatory process in Alzheimer's Disease

Marco A. Meraz-Rios et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2013)

Review Chemistry, Medicinal

Is RAGE still a therapeutic target for Alzheimer's disease?

Richard J. Deane

FUTURE MEDICINAL CHEMISTRY (2012)

Review Neurosciences

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

John F. Cryan et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Editorial Material Multidisciplinary Sciences

A Unifying Role for Prions in Neurodegenerative Diseases

Stanley B. Prusiner

SCIENCE (2012)

Review Multidisciplinary Sciences

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

Jose Miguel Rubio-Perez et al.

SCIENTIFIC WORLD JOURNAL (2012)

Article Clinical Neurology

Evidence for Ordering of Alzheimer Disease Biomarkers

Clifford R. Jack et al.

ARCHIVES OF NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Are Tangles as Toxic as They Look?

Tara L. Spires-Jones et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Review Biochemistry & Molecular Biology

Molecular mechanisms of neurodegeneration in Alzheimer's disease

Leslie Crews et al.

HUMAN MOLECULAR GENETICS (2010)

Article Neurosciences

Role of Mitochondrial Amyloid-beta in Alzheimer's Disease

John Xi Chen et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Medicine, General & Internal

Neuropathology of Alzheimer's Disease

Daniel P. Perl

MOUNT SINAI JOURNAL OF MEDICINE (2010)

Review Neurosciences

Neurochemical basis for symptomatic treatment of Alzheimer's disease

Paul T. Francis et al.

NEUROPHARMACOLOGY (2010)

Article Clinical Neurology

The Neuropathology of Probable Alzheimer Disease and Mild Cognitive Impairment

Julie A. Schneider et al.

ANNALS OF NEUROLOGY (2009)

Review Clinical Neurology

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

Review Biochemistry & Molecular Biology

Uptake and Dynamics of Infectious Prion Protein in the Intestine

Yasuhisa Ano et al.

PROTEIN AND PEPTIDE LETTERS (2009)

Article Biochemistry & Molecular Biology

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice

Lisa McConlogue et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Clinical Neurology

Common inflammatory mechanisms in Lewy body disease and Alzheimer disease

Robert E. Mrak et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)

Review Cardiac & Cardiovascular Systems

Cardiovascular risk factors for Alzheimer's disease

Clive Rosendoff et al.

AMERICAN JOURNAL OF GERIATRIC CARDIOLOGY (2007)

Review Clinical Neurology

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease

R. Schliebs et al.

JOURNAL OF NEURAL TRANSMISSION (2006)

Review Clinical Neurology

From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain

P. Riederer et al.

JOURNAL OF NEURAL TRANSMISSION (2006)

Review Medicine, General & Internal

Alzheimer's disease

Kaj Blennow et al.

LANCET (2006)

Article Geriatrics & Gerontology

Soluble Aβ homeostasis in AD and DS:: impairment of anti-amyloidogenic protection by lipoproteins

E Matsubara et al.

NEUROBIOLOGY OF AGING (2004)

Article Endocrinology & Metabolism

Steep disturbances are correlated with decreased morning awakening salivary cortisol

J Backhaus et al.

PSYCHONEUROENDOCRINOLOGY (2004)

Review Clinical Neurology

Memantine for the treatment of dementia

GK Wilcock

LANCET NEUROLOGY (2003)

Article Medicine, General & Internal

Memantine in moderate-to-severe Alzheimer's disease

B Reisberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Article Multidisciplinary Sciences

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

AD Alonso et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)