期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 86, 期 4, 页码 1897-1906出版社
IOS PRESS
DOI: 10.3233/JAD-215677
关键词
Cognitive health; dementia prevention; dietary/lifestyle factors; mild cognitive impairment; modifiable factors
资金
- Strategic Priority CAS Project [XDB38040200]
- Guang dong Philosophy and Social Science Fund [GD21Y SH06]
- Shenzhen Philosophy and Social Science Fund [SZ2020C015]
- Shenzhen Science and Technology Fund [2020080516 4059001]
- Shenzhen Science and Technology Program [KQTD20190929172835662, JCYJ20180703145002040]
This study identified several modifiable dietary/lifestyle factors associated with the reversion of mild cognitive impairment (MCI) to cognitive normal (CN) status, which may have important implications for large-scale dementia prevention practices.
Background: Previous studies found that about 24% of the mild cognitive impairment (MCI) patients reverse to cognitive normal (CN) status. However, it is unclear which modifiable factors are associated with this reversion. Objective: To identify potential modifiable factors associated with the reversion of MCI to CN status. Methods: We conducted a prospective community-based cohort study based on 2002-2018 Chinese Longitudinal Health Longevity Survey (CLHLS). Multivariable Cox regression with least absolute shrinkage and selection operator (LASSO) penalty for variable selection was adopted to investigate the associations between reversion to CN and potential modifiable dietary/lifestyle, cardiometabolic, and psychological factors. Results: Our analysis included 7,422 MCI participants [average age: 90.0 (SD 9.5) years]. Among these participants, 1,604 (21.6%) reversed from MCI to CN with a mean (SD) follow-up of 2.9 (1.8) years. Several dietary/lifestyle factors, including daily consumption of fresh fruits (Hazard Ratio [HR]: 1.28, 95% CI: 1.15 to 1.42), engagement in reading (HR: 1.24, 95% CI: 1.00 to 1.54), housework (HR: 1.21, 95% CI: 1.08 to 1.35), and mah-jongg or other card games (HR: 1.23, 95% CI: 1.08 to 1.39), were positively associated with possibility of reversion. Cigarette smoking (HR: 0.92, 95% CI: 0.84 to 1.00) and duration of alcohol drinking (HR: 0.97, 95% CI: 0.94 to 0.99) were negatively associated with possibility of reversion. None of the modifiable cardiometabolic and psychological factors was found to be significantly associated with reversion to CN. Conclusion: This study identified several dietary/lifestyle factors associated with MCI reversion that may transfer into large-scale dementia prevention practices.
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