☆ 4.7 Review

T cells in the skin: Lymphoma and inflammatory skin disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Letter Dermatology

Dupilumab unmasking cutaneous T-cell lymphoma: report of a fatal case

Elizabeth F. M. Poyner et al.

Summary: We present a case of a 60-year-old man who developed worsening of his skin condition and subsequently was diagnosed with cutaneous T cell lymphoma after receiving treatment with dupilumab for severe atopic dermatitis. The disease rapidly progressed and led to the patient's death 12 months after discontinuing dupilumab. This case adds to the existing evidence that dupilumab can cause CTCL progression and emphasizes the importance of re-evaluating patient diagnosis to exclude CTCL prior to initiating this biologic therapy.

CLINICAL AND EXPERIMENTAL DERMATOLOGY (2022)

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Review Oncology

Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways

Kalyani Patil et al.

Summary: Cutaneous T cell lymphomas (CTCLs) are a diverse group of lymphoproliferative neoplasms with varying immune, clinical, and histopathological features. Recent studies have used next-generation sequencing (NGS) to reveal genetic and epigenetic abnormalities that contribute to the development of CTCL. Malignant T cell clones in CTCL patients secrete cytokines and chemokines, creating a tumor microenvironment that favors T helper 2 (Th2)-type immune responses and promotes immune dysregulation and tumor growth. Understanding the molecular mechanisms, including the role of cytokines, chemokines, and signaling networks, in CTCL pathogenesis can lead to new therapeutic approaches.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Dermatology

Risk of lymphohematologic malignancies in patients with chronic plaque psoriasis: A systematic review with meta-analysis

Francesco Bellinato et al.

Summary: A systematic review and meta-analysis of 25 observational studies revealed a significantly increased risk of lymphohematologic malignancies, particularly Hodgkin lymphoma and cutaneous T-cell lymphoma, in patients with moderate-to-severe plaque psoriasis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Review Dermatology

Mouse Models of Psoriasis: A Comprehensive Review

Roopesh Singh Gangwar et al.

Summary: This comprehensive review compares and discusses genetic mouse models, xenograft approaches, and cytokine injections and topical imiquimod application in mice for studying psoriasis. It provides a detailed description and outcomes of these models and methods, serving as a valuable resource for researchers interested in working with psoriasis animal models.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Review Immunology

Significance of bystander T cell activation in microbial infection

Hoyoung Lee et al.

Summary: Bystander activation refers to the activation of pre-existing memory CD8(+) T cells by cytokines without cognate antigens, which can have protective or detrimental effects on the host depending on the infection model or disease. Research has elucidated the mechanisms and immunopathological roles of bystander activation in various microbial infections. T cell receptor-independent triggering of T cells, known as bystander activation, plays an important role in homeostatic antimicrobial responses and immunopathology.

NATURE IMMUNOLOGY (2022)

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Article Allergy

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

Daphne S. Bakker et al.

Summary: Atopic dermatitis (AD) is highly heterogeneous and can be stratified into biomarker-based endotypes. Through biomarker analysis, we identified four distinct clusters of AD patients, suggesting the potential for personalized therapies based on immunopathology.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

Lena Mobus et al.

Summary: Skin transcriptome studies in atopic dermatitis have shown core features of disturbed epidermal differentiation and IL-31/IL-1 signaling activation, along with type 2 inflammation, T(H)17 signaling, and natural killer cell function. IL4RA is a key dysregulated gene, and cyclosporine and dupilumab have distinct effects on the transcriptome in AD patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Dermatology

Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis

Amy S. Paller et al.

Summary: Tapinarof has shown significant efficacy in treating atopic dermatitis, improving severity of eczema and affected skin area. Patients' impressions of Tapinarof were generally positive. The results indicate that Tapinarof represents a potential important advancement in topical medicine development for atopic dermatitis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Rapid and sustained control of itch and reduction in Th2 bias by dupilumab in a patient with Sezary syndrome

O. Steck et al.

Summary: This study explored the clinical and immunological effects of type 2 cytokine blockade with dupilumab as supportive treatment in Sezary syndrome. The results showed rapid and sustained reduction in itch, improvement in skin and lymph node involvement, and a reduction in Th2 bias with dupilumab treatment.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Biochemistry & Molecular Biology

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Alexandra Schnell et al.

Summary: This study characterized the heterogeneity, plasticity, and migratory phenotypes of tissue Th17 cells in different states, revealing their roles in intestinal and central nervous system autoimmune inflammation. The research found that intestinal Th17 cells not only maintain tissue homeostasis but also directly contribute to the development of extra-intestinal autoimmune diseases.

CELL (2021)

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Article Dermatology

Mouse models of atopic dermatitis: a critical reappraisal

Amos Gilhar et al.

Summary: Mouse models for atopic dermatitis have limitations in reflecting the clinical complexity of human AD, and it is suggested that valid models should meet specific criteria to be considered relevant for human AD research. Humanized AD mouse models offer a promising alternative to current mouse models for preclinical research.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Dermatology

The immunopathogenesis and immunotherapy of cutaneous T cell lymphoma: Pathways and targets for immune restoration and tumor eradication

Joseph S. Durgin et al.

Summary: CTCLs are malignancies of skin-trafficking T cells, with patients experiencing immune dysfunction and susceptibility to infections. Therapies stimulating immunity show superior outcomes compared to conventional chemotherapy. Recent research has identified potential therapeutic targets by better understanding the pathogenesis of immune deficits in CTCL patients.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Review Pharmacology & Pharmacy

A deep dive into UV-based phototherapy: Mechanisms of action and emerging molecular targets in inflammation and cancer

Pablo A. Vieyra-Garcia et al.

Summary: UV-based phototherapy has a long and successful history in managing various skin disorders by regulating inflammation and inducing apoptosis of pathogenic cells. This therapy targets molecular elements in the skin microenvironment to promote clinical improvement in skin diseases.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds et al.

Summary: The skin establishes a complex cellular network early in embryonic development to provide biophysical and immunological protection. The study found an enrichment of innate immune cells in skin during the first trimester, as well as clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. Additionally, a reemergence of prenatal vascular endothelial cell and macrophage cellular programs was observed in atopic dermatitis and psoriasis lesional skin.

SCIENCE (2021)

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Article Immunology

Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

Christine Bangert et al.

Summary: Therapeutic options for autoimmune diseases typically involve immunosuppressive agents, but sustained clinical benefit is rare. A study on atopic dermatitis patients treated with dupilumab found decreases in skin immune cell counts and normalization of transcriptomic dysregulation. However, specific immune cell populations persisted after clinical remission, indicating a persisting disease memory.

SCIENCE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

Katharina Rindler et al.

Summary: The study identified a specific panel of biomarkers associated with disease progression in mycosis fungoides (MF) patients, which may be used for monitoring MF disease progression. Altered expression of these genes may underlie the switch in clinical phenotype observed in advanced-stage MF.

MOLECULAR CANCER (2021)

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Article Medicine, General & Internal

Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis

Mark G. Lebwohl et al.

Summary: Tapinarof cream used once daily was more effective in reducing the severity of plaque psoriasis over 12 weeks compared to vehicle control, but was associated with local adverse events and headache. Larger and longer trials are needed to evaluate the efficacy and safety of tapinarof cream.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Allergy

Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation

Kiyoshi Hirahara et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Cell Biology

TCR β chain-directed bispecific antibodies for the treatment of T cell cancers

Suman Paul et al.

Summary: Immunotherapies such as CAR T cells and bispecific antibodies have been successful in treating B cell malignancies, but require more selective targeting for T cell cancers. Targeting T cell cancers through TCR antigens provides a selective approach that preserves healthy T cells, maintaining cellular immunity.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Sarah Grosche et al.

Summary: This study identified rare and common variants associated with eczema susceptibility through a meta-analysis, revealing promising therapeutic targets and genetic characteristics of the disease. Rare variants were linked to up-regulation of skin genes while common variants were related to immune cell function.

NATURE COMMUNICATIONS (2021)

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Article Allergy

Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis

ZhengWang Sun et al.

Summary: The study found that CXCR4 and its ligand CXCL12 were significantly upregulated in the skin of humans with AD through global transcriptomic and proteomic analyses. Skin-resident CXCR4(+) NKT cells were enriched and consistently elevated in models of mice with AD, suggesting their potential role in contributing to AD pathogenesis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council

Yael Renert-Yuval et al.

Summary: Atopic dermatitis is a common yet complex skin disease with different phenotypes among patient populations, making therapeutic response variable. Biomarkers have the potential to improve precision medicine in AD, but further research is needed due to the complexity of the disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Psoriasis

Christopher E M Griffiths et al.

LANCET (2021)

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Article Chemistry, Medicinal

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

Haibin Zhou et al.

Summary: SD-91 is a potent, highly selective, and efficacious STAT3 degrader that effectively induces degradation of STAT3 protein with high selectivity, demonstrating complete and long-lasting tumor regression in preclinical models. It has the potential for extensive evaluations in the treatment of human cancers and diseases where STAT3 plays a critical role.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

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Article Immunology

Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells

Katharina Rindler et al.

Summary: Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, and little is known about the phenotypic and functional properties of malignant T cells in different tissue environments. The study found that malignant T cells exhibit different phenotypes, which may explain the multi-focal nature of the disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Hematology

Improved Sezary cell detection and novel insights into immunophenotypic and molecular heterogeneity in Sezary syndrome

Safa Najidh et al.

Summary: The study conducted immunophenotypic profiling of Sezary syndrome patients and found diverse phenotypes and different maturation states of Sezary cells. They also identified downregulated genes at the RNA level that can discriminate Sezary cells from normal CD4(+) T cells.

BLOOD (2021)

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Article Dermatology

Single-cell RNA sequencing profiling in a patient with discordant primary cutaneous B-cell and T-cell lymphoma reveals micromilieu-driven immune skewing

C. Jonak et al.

Summary: This study utilized single-cell RNA sequencing and T-cell and B-cell receptor sequencing to molecularly characterize a complex type of primary cutaneous lymphoma. The results revealed a patient with concurrent mycosis fungoides (MF) and primary cutaneous follicle centre lymphoma (PCFCL), with distinct immune phenotypes in the two types of lymphoma lesions. The data not only demonstrate the diagnostic potential of single-cell RNA sequencing, but also provide insights into the unique tissue microenvironment shaped by specific clonal populations in clinically distinct types of lymphoma skin lesions.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Allergy

Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases

Jennifer D. Hamilton et al.

Summary: Dupilumab can effectively suppress type 2 inflammatory biomarkers in specific diseases and its impact on blood eosinophil responses varies by disease.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Review Allergy

JAK inhibitors in the treatment of atopic dermatitis

Raj Chovatiya et al.

Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Dermatology

Jak-STAT Inhibition Mediates Romidepsin and Mechlorethamine Synergism in Cutaneous T-Cell Lymphoma

Jose R. Cortes et al.

Summary: The combination of romidepsin with mechlorethamine has shown synergistic antilymphoma effects in Se’zary syndrome, with downregulation of STAT5 phosphorylation being a key mediator of this interaction. Jak/STAT signaling plays a previously unrecognized role in the response to romidepsin and romidepsin-based combination therapies in Se' zary syndrome.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Pharmacology & Pharmacy

Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy

Rebecca L. Best et al.

Summary: The study demonstrates that MMAE extensively binds to tubulin and microtubules, causing severe microtubule dysregulation and leading to neurodegenerative diseases. MMAE suppresses cell proliferation, mitosis, and microtubule dynamics, disrupting the microtubule network through non-specific uptake.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Review Medicine, General & Internal

Cutaneous T cell lymphoma

Reinhard Dummer et al.

Summary: Primary cutaneous T cell lymphomas are a diverse group of lymphomas with complex pathophysiology and require interdisciplinary collaboration for diagnosis and treatment. Current treatment options include skin-directed and systemic therapies, with allogeneic hematopoietic stem cell transplantation being the only curative approach. Further research is needed for better treatment strategies.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Review Rheumatology

Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis: a systematic review

Conor Magee et al.

Summary: The current study indicates that some biomarkers may be associated with treatment response in psoriatic disease, however, due to the diversity in research methods and outcomes, firm conclusions cannot be drawn and further validation is needed.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2021)

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Review Allergy

The Concept of Pathogenic TH2 Cells: Collegium Internationale Allergologicum Update 2021

Nicole L. Bertschi et al.

Summary: T helper (T-H) cells have distinct subsets that mediate specific immune responses. Allergic diseases may be caused by a specific pathogenic subpopulation of T(H)2 cells, which share core phenotypes and overlapping functional attributes. The unique characteristics of pathogenic T(H)2 cells are currently being discovered.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

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Review Allergy

Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis

Thomas Bieber

ALLERGY (2020)

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Article Allergy

Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation

Alexandra Leonard et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Dermatology

Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma

Jingkai Xu et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2020)

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Editorial Material Allergy

Reconciling innate and acquired immunity in atopic dermatitis

Tetsuya Honda et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis

Consol Farrera et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

Helen He et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Oncology

The Th9 Axis Reduces the Oxidative Stress and Promotes the Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma Patients

Sushant Kumar et al.

MOLECULAR CANCER RESEARCH (2020)

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Article Dermatology

Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis A Phase 2b Randomized Clinical Trial

Emma Guttman-Yassky et al.

JAMA DERMATOLOGY (2020)

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Review Immunology

Itch: A Paradigm of Neuroimmune Crosstalk

Fang Wang et al.

IMMUNITY (2020)

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Article Allergy

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type-specific immune regulation in atopic dermatitis

Thomas B. Rojahn et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Dermatology

The current landscape of psoriasis genetics in 2020

Kotaro Ogawa et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2020)

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Letter Dermatology

Progression of cutaneous T-cell lymphoma after dupilumab: Case review of 7 patients

Maria L. Espinosa et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

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Article Oncology

Primary Cutaneous Lymphomas Version 2.2020 Featured Updates to the NCCN Guidelines

Neha Mehta-Shah et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

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Article Dermatology

Association Between Atopic Eczema and Cancer in England and Denmark

Kathryn E. Mansfield et al.

JAMA DERMATOLOGY (2020)

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Article Medicine, Research & Experimental

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

Sherrie J. Divito et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Hematology

Robust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma

Masato Saito et al.

BLOOD ADVANCES (2020)

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Review Immunology

Current knowledge on autoantigens and autoantibodies in psoriasis

Lisa Lynn ten Bergen et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2020)

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Article Cell Biology

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

Johanna Strobl et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Dermatology

Cutaneous T-cell Lymphoma and Concomitant Atopic Dermatitis Responding to Dupilumab

Nicholas K. Mollanazar et al.

CUTIS (2020)

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Review Dermatology

Psoriasis and Genetics

Nick Dand et al.

ACTA DERMATO-VENEREOLOGICA (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Feasibility of CXCR4-Directed Radioligand Therapy in Advanced Diffuse Large B-Cell Lymphoma

Constantin Lapa et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Article Allergy

Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

Emma Guttman-Yassky et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab

Patrick M. Brunner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Cell Biology

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

Donald Y. M. Leung et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Oncology

CAR-Based Approaches to Cutaneous T-Cell Lymphoma

Irene Scarfo et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Hematology

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

Lise M. Lindahl et al.

BLOOD (2019)

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Article Multidisciplinary Sciences

TOX is a critical regulator of tumour-specific T cell differentiation

Andrew C. Scott et al.

NATURE (2019)

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Article Immunology

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

Maria M. Klicznik et al.

SCIENCE IMMUNOLOGY (2019)

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Review Immunology

Autoimmunity (or Not) in Atopic Dermatitis

Lennart M. Roesner et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Targeting T Cell Metabolism in Inflammatory Skin Disease

Leonhard von Meyenn et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Allergy

Skin disorders are prominent features in primary immunodeficiency diseases: A systematic overview of current data

Jill de Wit et al.

ALLERGY (2019)

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Article Cell Biology

Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1

Ozge Uluckan et al.

CELL REPORTS (2019)

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Article Dermatology

The rash that becomes an erythroderma

Arun C. Inamadar et al.

CLINICS IN DERMATOLOGY (2019)

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Review Genetics & Heredity

Genomic alterations driving psoriasis pathogenesis

S. Singh et al.

GENE (2019)

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Review Allergy

Atopic dermatitis endotypes and implications for targeted therapeutics

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Dermatology

Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

Lam C. Tsoi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Article Oncology

Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sezary syndrome

Florian Anzengruber et al.

LEUKEMIA & LYMPHOMA (2019)

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Article Immunology

Defining 'T cell exhaustion'

Christian U. Blank et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Immunology

Human TH9 cells are a subpopulation of PPAR-γ+ TH2 cells

Claire Micosse et al.

SCIENCE IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma

Pablo Vieyra-Garcia et al.

JCI INSIGHT (2019)

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Review Oncology

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautes-Fridman et al.

NATURE REVIEWS CANCER (2019)

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Letter Dermatology

The Duvic regimen for erythrodermic flares secondary to Staphylococcus aureus in mycosis fungoides and Sezary syndrome

Daniel J. Lewis et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2018)

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Review Dermatology

The role of the microbiome in psoriasis: moving from disease description to treatment selection?

E. A. Langan et al.

BRITISH JOURNAL OF DERMATOLOGY (2018)

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Article Allergy

Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration

Hansjorg Baurecht et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Oncology

Pathogenesis of Enteropathy-Associated T Cell Lymphoma

Udit Chander et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2018)

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Article Allergy

Methotrexate Versus Cyclosporine in Adults with Moderate-to-Severe Atopic Dermatitis: A Phase III Randomized Noninferiority Trial

Catherine Goujon et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

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Article Medicine, General & Internal

Atopic dermatitis

Stephan Weidinger et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Article Biochemical Research Methods

Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections

Fredrik Salmen et al.

NATURE PROTOCOLS (2018)

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Article Hematology

Single-cell heterogeneity in Sezary syndrome

Terkild Brink Buus et al.

BLOOD ADVANCES (2018)

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Article Medicine, Research & Experimental

Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A

Alexander A. Merleev et al.

JCI INSIGHT (2018)

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Review Biotechnology & Applied Microbiology

Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy

Jogender Tushir-Singh

EXPERT OPINION ON BIOLOGICAL THERAPY (2017)

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Article Immunology

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

Takanori Hidaka et al.

NATURE IMMUNOLOGY (2017)

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Review Immunology

TH9 cells in skin disorders

Rachael A. Clark et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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Review Oncology

European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome - Update 2017

Franz Trautinger et al.

EUROPEAN JOURNAL OF CANCER (2017)

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Article Allergy

β-Defensin 2 is a responsive biomarker of IL-17A-driven skin pathology in patients with psoriasis

Frank Kolbinger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Medicine, Research & Experimental

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing αβ T cell clones

Tiago R. Matos et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Immunology

Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway

Hongfei Lou et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Dermatology

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

Susan H. Smith et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Dermatology

An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease

Benjamin Ungar et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Dermatology

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council

Eric L. Simpson et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

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Article Dermatology

Phase I randomized study of KHK4083, an anti-OX40 monoclonal antibody, in patients with mild to moderate plaque psoriasis

K. A. Papp et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Article Biochemical Research Methods

Simultaneous epitope and transcriptome measurement in single cells

Marlon Stoeckius et al.

NATURE METHODS (2017)

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Article Cell Biology

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders

Erik Wambre et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Oncology

Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators

Ivan V. Litvinov et al.

ONCOIMMUNOLOGY (2017)

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Article Allergy

Nonlesional atopic dermatitis skin shares similar T-cell clones with lesional tissues

P. M. Brunner et al.

ALLERGY (2017)

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Article Hematology

Circulating and skin-derived Sezary cells: clonal but with phenotypic plasticity

Marie Roelens et al.

BLOOD (2017)

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Review Immunology

Autoimmune aspects of psoriasis: Heritability and autoantigens

Joerg Christoph Prinz

AUTOIMMUNITY REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

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Article Hematology

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)

Joonhee Park et al.

BLOOD (2017)

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Review Immunology

The dichotomous nature of T helper 17 cells

Brigitta Stockinger et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Review Immunology

IL-17 and IL-22 in immunity: Driving protection and pathology

Kilian Eyerich et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

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Article Oncology

STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides

Pablo A. Vieyra-Garcia et al.

CLINICAL CANCER RESEARCH (2016)

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Review Immunology

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

Ana C. Anderson et al.

IMMUNITY (2016)

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Article Dermatology

Secukinumab improves patient-reported psoriasis symptoms of itching, pain, and scaling: results of two phase 3, randomized, placebo-controlled clinical trials

Bruce Strober et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2016)

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Article Immunology

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease

Evangelia Kourepini et al.

JOURNAL OF IMMUNOLOGY (2016)

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Review Oncology

T-cell Lymphoma Epidemiology: the Known and Unknown

Anh Phan et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2016)

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Article Hematology

Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation

Larisa J. Geskin et al.

BLOOD (2015)

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Article Immunology

Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis

Tetsuro Kobayashi et al.

IMMUNITY (2015)

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Article Dermatology

Malignant T Cells Secrete Galectins and Induce Epidermal Hyperproliferation and Disorganized Stratification in a Skin Model of Cutaneous T-Cell Lymphoma

Christenze Thode et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Article Dermatology

CD158k Is a Reliable Marker for Diagnosis of Sezary Syndrome and Reveals an Unprecedented Heterogeneity of Circulating Malignant Cells

Helene Moins-Teisserenc et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

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Review Dermatology

Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis

Laureline Legendre et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Genetics & Heredity

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster et al.

NATURE GENETICS (2015)

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Article Immunology

Innate immunological function of TH2 cells in vivo

Liying Guo et al.

NATURE IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Takeya Adachi et al.

NATURE MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Common clonal origin of central and resident memory T cells following skin immunization

Olivier Gaide et al.

NATURE MEDICINE (2015)

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Article Cell Biology

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

Rei Watanabe et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Review Cell Biology

Resident memory T cells in human health and disease

Rachael A. Clark

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Hematology

Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma

Yuanshen Huang et al.

BLOOD (2015)

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Article Immunology

CCR4 and its ligands: from bench to bedside

Osamu Yoshie et al.

INTERNATIONAL IMMUNOLOGY (2015)

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Article Immunology

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

Nicole Joller et al.

IMMUNITY (2014)

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Article Dermatology

Exploring the IL-21-STAT3 Axis as Therapeutic Target for Sezary Syndrome

Leslie van der Fits et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Article Medicine, General & Internal

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Lisa A. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Cell Biology

Human TH9 Cells Are Skin-Tropic and Have Autocrine and Paracrine Proinflammatory Capacity

Christoph Schlapbach et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Article Oncology

TH2 Cytokines from Malignant Cells Suppress TH1 Responses and Enforce a Global TH2 Bias in Leukemic Cutaneous T-cell Lymphoma

Emmanuella Guenova et al.

CLINICAL CANCER RESEARCH (2013)

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Article Hematology

Galectins in hematological malignancies

Mirta Giordano et al.

CURRENT OPINION IN HEMATOLOGY (2013)

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Article Biochemistry & Molecular Biology

The altered landscape of the human skin microbiome in patients with primary immunodeficiencies

Julia Oh et al.

GENOME RESEARCH (2013)

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Article Dermatology

Increased CCL18 expression in patients with cutaneous T-cell lymphoma: association with disease severity and prognosis

T. Miyagaki et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2013)

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Review Multidisciplinary Sciences

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

Lisa M. Coussens et al.

SCIENCE (2013)

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Editorial Material Dermatology

IL-33: A Novel Danger Signal System in Atopic Dermatitis

Ferda Cevikbas et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Cell Biology

Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients

Rachael A. Clark et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Letter Dermatology

Dilute Bleach Baths for Staphylococcus aureus Colonization in Atopic Dermatitis to Decrease Disease Severity

Jennifer T. Huang et al.

ARCHIVES OF DERMATOLOGY (2011)

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Article Oncology

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Tomomitsu Miyagaki et al.

CLINICAL CANCER RESEARCH (2011)

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Article Dermatology

IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?

Malene Hvid et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Dermatology

Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: A randomized controlled trial

Inge M. Haeck et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2011)

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Article Immunology

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells

Sabina A. Islam et al.

NATURE IMMUNOLOGY (2011)

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Article Hematology

Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors

James J. Campbell et al.

BLOOD (2010)

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Review Dermatology

Extrinsic and intrinsic types of atopic dermatitis

Yoshiki Tokura

JOURNAL OF DERMATOLOGICAL SCIENCE (2010)

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Article Dermatology

Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling

Tao Zheng et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Review Immunology

Homeostasis of Naive and Memory T Cells

Charles D. Surh et al.

IMMUNITY (2008)

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Article Dermatology

Cucurbitacin I inhibits Stat3 and induces apoptosis in Sezary cells

Marloes S. van Kester et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

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Review Cell Biology

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

Lai Wei et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)

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Article Dermatology

Filaggrin null alleles are not associated with psoriasis

Yiwei Zhao et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Immunology

Cutting edge: Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions

James J. Campbell et al.

JOURNAL OF IMMUNOLOGY (2007)

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Review Immunology

The pathogenic role of tissue-resident immune cells in psoriasis

Onur Boyman et al.

TRENDS IN IMMUNOLOGY (2007)

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Letter Dermatology

Filaggrin R501X and 2282del4 mutations are not associated with chronic plaque-type psoriasis in a German cohort

Michael Weichenthal et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Immunology

Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

J Yoo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Article Immunology

The immunological basis of lichenoid tissue reaction

T Shiohara et al.

AUTOIMMUNITY REVIEWS (2005)

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Article Immunology

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

K Boniface et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Immunology

Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α

O Boyman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Immunology

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

SR Dillon et al.

NATURE IMMUNOLOGY (2004)

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Article Immunology

IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition

DK Sojka et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Oncology

NF-kappa B expression in oral and cutaneous lichen planus

A Santoro et al.

JOURNAL OF PATHOLOGY (2003)

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Article Dermatology

Thymus and activation-regulated chemokine (TARC/CCL17) in mycosis fungoides: Serum TARC levels reflect the disease activity of mycosis fungoides

T Kakinuma et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2003)

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Article Dermatology

Cutaneous T-cell lymphoma and atopy: is there an association?

K Mehrany et al.

BRITISH JOURNAL OF DERMATOLOGY (2003)

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Article Multidisciplinary Sciences

IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

H Konishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Review Immunology

Epitope spreading in immunemediated diseases: Implications for immunotherapy

CL Vanderlugt et al.

NATURE REVIEWS IMMUNOLOGY (2002)

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Article Dermatology

Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: An experimental animal model to study atopic dermatitis

LS Chan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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Article Dermatology

Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions

M Hindsén et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2001)

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