Design, Synthesis, and Biological Evaluation of Novel Psoralen-Based 1,3,4-Oxadiazoles as Potent Fungicide Candidates Targeting Pyruvate Kinase

Article Biochemistry & Molecular Biology

Design, synthesis and antifungal activity of (E)-3-acyl-5-(methoxyimino)-1,5-dihydrobenzo[e][1,2]oxazepin-4(3H)-one analogues

Dongyan Yang et al.

Summary: This study designed and synthesized novel nitrogen or oxygen-containing analogues with significant antifungal activity. Some of the compounds exhibited high inhibitory rates against various pathogens.

MOLECULAR DIVERSITY (2021)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Antifungal Activity of Novel Thiophene/Furan-1,3,4-Oxadiazole Carboxamides as Potent Succinate Dehydrogenase Inhibitors

Zihui Yang et al.

Summary: By synthesizing 30 novel thiophene/furan-1,3,4-oxadiazole carboxamide derivatives, compounds with potential antifungal activity, especially compound 4i, were discovered in the in vitro antifungal assay. In vivo antifungal assays showed that compounds 4g and 4i were effective in suppressing Sclerotinia rot. In the SDH inhibition assay, compounds 4g and 4i demonstrated significant inhibitory activity, suggesting their potential as novel SDH inhibitors.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors

Yan-En Wang et al.

Summary: Compounds 5av and 5aw showed excellent herbicidal activity in vitro, with over 90% inhibition against tested weeds at concentrations as low as 100 mg/L. Furthermore, they exhibited higher postemergence herbicidal activity than positive controls in a greenhouse setting, while being safe for crops of maize and wheat. Fluorescent binding experiments and molecular docking analyses indicated strong TK inhibitory activity of 5av and 5aw, making them promising herbicide candidates for weed control in wheat and maize fields.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Chemistry, Medicinal

Apoptosis Inducing 1,3,4-Oxadiazole Conjugates of Capsaicin: Their In Vitro Antiproliferative and In Silico Studies

Fatima Naaz et al.

Summary: A series of 1,3,4-oxadiazole tethered capsaicin derivatives were synthesized by modifying the vanillyl-hydroxyl group of capsaicin, with compound 20a showing promising cytotoxic activity against various cancer cell lines. Compound 20a induced apoptosis, inhibited colony formation, had antimigratory properties, and suppressed certain protein markers in a dose-dependent manner, supported by in silico studies showing interaction with VEGFR2 protein.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

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Article Chemistry, Analytical

TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells

Dong Wang et al.

Summary: In this study, a novel AIE probe TEPC466 was synthesized for selective detection of PKM2 protein, showing high selectivity and sensitivity. The probe was successfully used in imaging colorectal cancer cells and demonstrated better binding to PKM2 than TEPP-46, suggesting its potential as an agonist for PKM2. This bioprobe holds promise in selective PKM2 detection and could be a useful tool for cancer diagnosis and therapy.

ANALYTICAL CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound

Weibo Wang et al.

Summary: The rational design and synthesis of novel isothiazolepurine derivatives for pyruvate kinase (PK)-based fungicide development led to the discovery of compounds with excellent in vitro activity against various fungal pathogens, showing promise for further study.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles

Shichuang Ma et al.

Summary: A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure were synthesized and evaluated for their insecticidal activity against several aphid species, showing promising results. The compounds demonstrated potential insecticidal effects by disrupting mitochondria and nuclear membranes in insect midgut cells, particularly against Eriosoma lanigerum. Further studies also indicated the inhibitory action of one compound on carboxylesterase in the target insect, suggesting its potential as a new pesticide.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Agriculture, Multidisciplinary

Development of Novel Pesticides Targeting Insect Chitinases: A Minireview and Perspective

Wei Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Structure-Activity Relationship of Novel Spiropyrimidinamines as Fungicides against Pseudoperonospora cubensis

Jinlong Yang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole-Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors

Bin Yu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agriculture, Multidisciplinary

Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents

Yanan Hao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Agriculture, Multidisciplinary

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Xiao-Dan Yin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Chemistry, Organic

Synthesis and Activity of New Schiff Bases of Furocoumarin

Huijun Xie et al.

HETEROCYCLIC COMMUNICATIONS (2020)

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Article Agriculture, Multidisciplinary

Antifungal Activity of Griseofulvin Derivatives against Phytopathogenic Fungi in Vitro and in Vivo and Three-Dimensional Quantitative Structure-Activity Relationship Analysis

Yu-Bin Bai et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Plant Sciences

Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation

Unwoo Kang et al.

JOURNAL OF NATURAL PRODUCTS (2019)

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Article Agriculture, Multidisciplinary

Discovery of Novel Isothiazole, 1,2,3-Thiadiazole, and Thiazole-Based Cinnamamides as Fungicidal Candidates

Lai Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Agriculture, Multidisciplinary

Synthesis and Biological Activity of Novel Succinate Dehydrogenase Inhibitor Derivatives as Potent Fungicide Candidates

Dongyan Yang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Synthesis, biological activities and 3D-QSAR studies of (R)-2-phenyl-4,5-dihydrothiazole-4-carboxamide derivatives containing a sulfur ether moiety

Jingbo Liu et al.

CHINESE CHEMICAL LETTERS (2019)

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Article Agriculture, Multidisciplinary

Discovery of Novel Piperidinylthiazole Derivatives As Broad-Spectrum Fungicidal Candidates

Qifan Wu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Chemistry, Multidisciplinary

Design, Synthesis and Biological Evaluation of Isothiazole Based 1,2,4-Trizaole Derivatives

Lai Chen et al.

CHINESE JOURNAL OF CHEMISTRY (2018)

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Article Agriculture, Multidisciplinary

Marine-Natural-Product Development: First Discovery of Nortopsentin Alkaloids as Novel Antiviral, Anti-phytopathogenic-Fungus, and Insecticidal Agents

Xiaofei Ji et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Agriculture, Multidisciplinary

Synthesis of Novel 3,4-Chloroisothiazole-Based Imidazoles as Fungicides and Evaluation of Their Mode of Action

Lai Chen et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Chemistry, Medicinal

Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors

Claudia Melis et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

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Article Food Science & Technology

Transketolase Is Identified as a Target of Herbicidal Substance alpha-Terthienyl by Proteomics

Bin Zhao et al.

TOXINS (2018)

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Article Chemistry, Multidisciplinary

The mechanism of antibacterial activity of corylifolinin against three clinical bacteria from Psoralen corylifolia L

Nan He et al.

OPEN CHEMISTRY (2018)

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Article Agriculture, Multidisciplinary

Discovery of Pyruvate Kinase as a Novel Target of New Fungicide Candidate 3-(4-Methyl-1,2,3-thiadiazolyl)-6-trichloromethyl-[1,2,4]-triazolo-[3,4-b]-[1,3,4]-thiadizole

Bin Zhao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Review Agriculture, Multidisciplinary

Pesticide Interactions: Mechanisms, Benefits, and Risks

John E. Casida

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Article Biochemistry & Molecular Biology

DockingApp: a user friendly interface for facilitated docking simulations with AutoDock Vina

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Design, Synthesis, Acaricidal/Insecticidal Activity, and Structure-Activity Relationship Studies of Novel Oxazolines Containing Sulfone/Sulfoxide Groups Based on the Sulfonylurea Receptor Protein-Binding Site

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Counting on natural products for drug design

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Design, synthesis and structure-activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans

Ya-Qiang Xie et al.

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Synthesis of novel psoralen analogues and their in vitro antitumor activity

Carla S. Francisco et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

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Synthesis and biological evaluation of glycosylated psoralen derivatives

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TETRAHEDRON (2012)

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Article Biochemistry & Molecular Biology

Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies

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Synthesis, Crystal Structure, and Biological Activity of 4-Methyl-1,2,3-thiadiazole-Containing 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazoles

Zhuin Fan et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

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Article Chemistry, Multidisciplinary

Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading

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Article Multidisciplinary Sciences

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Design, Synthesis, and Biological Evaluation of Novel Psoralen-Based 1,3,4-Oxadiazoles as Potent Fungicide Candidates Targeting Pyruvate Kinase

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