4.7 Review

Phloroglucinol and Its Derivatives: Antimicrobial Properties toward Microbial Pathogens

期刊

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 16, 页码 4817-4838

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c00532

关键词

Antibacterial; Antifungal; Antiviral; Derivatives; Phloroglucinol

资金

  1. Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education [2021R1A6A1A03039211, 2022R1A2B5B01001998]
  2. National Research Foundation of Korea [2022R1A2B5B01001998] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Phloroglucinol and its derivatives have been widely used to treat microbial infections and exhibit diverse biological activities. With the increasing resistance of microorganisms to antimicrobial drugs, the synthesis of more phloroglucinol derivatives is crucial to meet the growing demand. This review provides an overview of the application of phloroglucinol and its derivatives in antibacterial action and explores their potential future perspectives.
Phloroglucinol (PG) is a natural product isolated from plants, algae, and microorganisms. Aside from that, the number of PG derivatives has expanded due to the discovery of their potential biological roles. Aside from its diverse biological activities, PG and its derivatives have been widely utilized to treat microbial infections caused by bacteria, fungus, and viruses. The rapid emergence of antimicrobial-resistant microbial infections necessitates the chemical synthesis of numerous PG derivatives in order to meet the growing demand for drugs. This review focuses on the use of PG and its derivatives to control microbial infection and the underlying mechanism of action. Furthermore, as future perspectives, some of the various alternative strategies, such as the use of PG and its derivatives in conjugation, nanoformulation, antibiotic combination, and encapsulation, have been thoroughly discussed. This review will enable the researcher to investigate the possible antibacterial properties of PG and its derivatives, either free or in the form of various formulations.

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