4.7 Review

Sustained attention alterations in major depressive disorder: A review of fMRI studies employing Go/No-Go and CPT tasks

期刊

JOURNAL OF AFFECTIVE DISORDERS
卷 303, 期 -, 页码 98-113

出版社

ELSEVIER
DOI: 10.1016/j.jad.2022.02.003

关键词

Major depressive disorder; fMRI; Review; Go/No-Go; CPT; Attention networks; Cognitive networks

资金

  1. Italian Ministry of Health [GR-2018-12367789]

向作者/读者索取更多资源

This review summarizes the current evidence from functional magnetic resonance imaging (fMRI) studies investigating sustained attention in patients with major depressive disorder (MDD). The results indicate quantitative alterations in key brain regions involved in attention, executive control, and default mode networks during attention tasks in MDD patients. However, the generalizability of the results is limited due to heterogeneity in study designs and fMRI acquisition techniques and processing methods.
Background: Major depressive disorder (MDD) is a severe psychiatric condition characterized by selective cognitive dysfunctions. In this regard, functional Magnetic Resonance Imaging (fMRI) studies showed, both at resting state and during tasks, alterations in the brain functional networks involved in cognitive processes in MDD patients compared to controls. Among those, it seems that the attention network may have a role in the disease pathophysiology. Therefore, in this review we aim at summarizing the current fMRI evidence investigating sustained attention in MDD patients. Methods: We conducted a search on PubMed on case-control studies on MDD employing fMRI acquisitions during Go/No-Go and continuous performance tasks. A total of 12 studies have been included in the review. Results: Overall, the majority of fMRI studies reported quantitative alterations in the response to attentive tasks in selective brain regions, including the prefrontal cortex, the cingulate cortex, the temporal and parietal lobes, the insula and the precuneus, which are key nodes of the attention, the executive, and the default mode networks. Limitations: The heterogeneity in the study designs, fMRI acquisition techniques and processing methods have limited the generalizability of the results. Conclusions: The results from the included studies showed the presence of alterations in the activation patterns of regions involved in sustained attention in MDD, which are in line with current evidence and seemed to explain some of the key symptoms of depression. However, given the paucity and heterogeneity of studies available, it may be worthwhile to continue investigating the attentional domain in MDD with ad-hoc study designs to retrieve more robust evidence.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据