期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 301, 期 -, 页码 437-444出版社
ELSEVIER
DOI: 10.1016/j.jad.2022.01.035
关键词
Anterior cingulate cortex; Cingulum bundle; Cortical thickness; White matter; Melancholia; depression
资金
- Robert Enke Foundation
- Swiss Life Foundation
- Novartis Foundation for medical biological research
- Adrian et Simone Frutiger Foundation
This study investigates the structural and white matter microstructural alterations in the anterior cingulate cortex (ACC) in major depressive disorder. The results suggest that reduced cortical thickness of the caudal ACC is associated with the melancholic subtype of depression, and white matter microstructure of the cingulum bundle (CB) may serve as a marker of depression severity.
Background: Structural and functional alterations of the anterior cingulate cortex (ACC) have been related to emotional, cognitive and behavioral domains of major depressive disorder. In this study, we investigate cortical thickness of rostral and caudal ACC. In addition, we explore white matter microstructure of the cingulum bundle (CB), a white matter pathway connecting multiple segments of the ACC. We hypothesized reduced cortical thickness and reduced white matter microstructure of the CB in MDD, in particular in the melancholic subtype. In addition, we expect an association between depression severity and CB microstructure. Methods: Fifty-four patients with a current depressive episode and 22 healthy controls matched for age, gender and handedness underwent structural and diffusion-weighted MRI-scans. Cortical thickness of rostral and caudal ACC were computed. The CB was reconstructed bilaterally using manual tractography. Cortical thickness and fractional anisotropy (FA) of bilateral CB were compared first between all patients and healthy controls and second between healthy controls, melancholic and non-melancholic patients. Correlations between FA and depression severity were calculated. Results: We found no group differences in rostral and caudal ACC cortical thickness or in FA of the CB comparing all patients with healthy controls. Melancholic patients had reduced cortical thickness of bilateral caudal ACC compared to non-melancholic patients and compared to healthy controls. Across all patients, depression severity was associated with reduced FA in bilateral CB. Limitations: Impact of medication Conclusions: Cortical thickness of the caudal ACC is associated with the melancholic syndrome. CB microstructure may represent a marker of depression severity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据