4.7 Article

Disrupted olfactory functional connectivity in patients with late-life depression

期刊

JOURNAL OF AFFECTIVE DISORDERS
卷 306, 期 -, 页码 174-181

出版社

ELSEVIER
DOI: 10.1016/j.jad.2022.03.014

关键词

Late-life depression; Alzheimer's disease; Odor identification; Functional connectivity; MRI

资金

  1. National Natural Science Foundation of China [81701341, 82101508]
  2. Guangzhou Municipal Psychiatric Diseases Clinical Transformation Laboratory [201805010009]
  3. Science and Technology Plan Project of Guangdong Province [2019B030316001]
  4. National Key Research and Development Program of China [2016YFC0906300]
  5. Key Laboratory for Innovation platform Plan, Science and Technology Program of Guangzhou, China

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This study found that LLD patients with OI impairment exhibited more disrupted olfactory functional connectivity (FC), which may serve as an indicator of dementia risk. The abnormal FCs were associated with OI, global cognition, and language function scores, and the FC between the right piriform cortex and right superior parietal lobule partially mediated the relationship between OI and MMSE scores.
Background: Odor identification (OI) impairment increases the risk of Alzheimer's disease and brain abnormalities in patients with late-life depression (LLD). However, it remains unclear whether abnormal functional connectivity (FC) of olfactory regions is involved in the relationship between OI impairment and dementia risk in LLD patients. The current study aims to explore the olfactory FC patterns of LLD patients and how olfactory FCs mediate the relationship between OI and cognition. Methods: A total of 150 participants underwent resting-state functional magnetic resonance imaging and psychometric and olfactory assessments. The primary and secondary olfactory regions were selected as regions of interest to investigate olfactory FC patterns and their association with OI and cognitive performance in LLD patients. Results: Compared with LLD patients without OI impairment and normal controls, LLD patients with OI impairment exhibited increased FC between the left orbital frontal cortex (OFC) and left calcarine gyrus, between the left OFC and right lingual gyrus, between the right OFC and right rectus gyrus, and decreased FC between the right piriform cortex and right superior parietal lobule. Additionally, these abnormal FCs were associated with scores of OI, global cognition and language function. Finally, the FC between the right piriform cortex and right superior parietal lobule exhibited a partially mediated effect on the relationship between OI and MMSE scores. Limitations: The present study did not exclude the possible effect of drugs. Conclusion: LLD patients with OI impairment exhibited more disrupted olfactory FC (a decrease in the primary olfactory cortex and an increase in the secondary olfactory cortex) than LLD patients with intact OI, and these abnormal FCs may serve as potential targets for neuromodulation in LLD patients to prevent them from developing dementia.

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