期刊
CANCER BIOLOGY & THERAPY
卷 16, 期 4, 页码 511-517出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2015.1017691
关键词
apoptosis; autophagy; colorectal cancer; HMGB1; MEK; ERK pathway; oxaliplatin
类别
资金
- National Natural Science Foundation of China [30860257, 81101188, 810701297]
- Yunnan Provincial Department of Education [ZD2011007]
In the present study, we examined the mechanisms of oxaliplatin-induced drug resistance in human colorectal cancer cell lines HT29 and HCT116. Our results demonstrate a significant autophagy expression in CRC cells after an oxaliplatin treatment. Administration of oxaliplatin to human CRC cells significantly enhanced the expression of HMGB1, which regulated the autophagy response and negatively regulate the cell apoptosis. Moreover, a decreased oxaliplatin -induced autophagy response and an increased apoptosis level were detected in stable CRC cells harboring HMGB1 shRNA. Then we noted that HMGB1 significantly induced extracellular signal-regulated kinase (ERK)/Extracellular signal-regulated kinase kinase (MEK) phosphorylation. Taken together, these data suggest that HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.
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