A combination of sugar esters and chitosan to promote in vivo wound care

In recent years, researchers are exploring innovative green materials fabricated from renewable natural sub-stances to meet formulation needs. Among them, biopolymers like chitosans and biosurfactants such as sugar fatty acid esters are of potential interest due to their biocompatibility, biodegradability, functionality, and cost-effectiveness. Both classes of biocompounds possess the ability to be efficiently employed in wound dressing to help physiological wound healing, which is a bioprocess involving uncontrolled oxidative damage and inflam-mation, with an associated high risk of infection. In this work, we synthesized two different sugar esters (i.e., lactose linoleate and lactose linolenate) that, in combination with chitosan and sucrose laurate, were evaluated in vitro for their cytocompatibility, anti-inflammatory, antioxidant, and antibacterial activities and in vivo as wound care agents. Emphasis on Wnt/beta-catenin associated machineries was also set. The newly designed lactose esters, sucrose ester, and chitosan possessed sole biological attributes, entailing considerable blending for convenient formulation of wound care products. In particular, the mixture composed of sucrose laurate (200 mu M), lactose linoleate (100 mu M), and chitosan (1%) assured its superiority in terms of efficient wound healing prospects in vivo together with the restoring of the Wnt/beta-catenin signaling pathway, compared with the marketed wound healing product (Healosol (R)), and single components as well. This innovative combination of biomaterials applied as wound dressing could effectively break new ground in skin wound care.

Automated summary

Researchers have been exploring innovative green materials made from renewable natural substances, such as chitosans and biosurfactants, for formulation needs. These biopolymers possess biocompatibility, biodegradability, functionality, and cost-effectiveness. They have shown potential for wound dressing to aid in physiological wound healing, which involves oxidative damage, inflammation, and infection risks. The study synthesized different sugar esters in combination with chitosan and sucrose laurate and evaluated their cytocompatibility, anti-inflammatory, antioxidant, and antibacterial activities. The combination showed superior wound healing prospects and restoration of the Wnt/beta-catenin signaling pathway.