期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 617, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.121448
关键词
Antimicrobial formulations; Hydrogels; Mucoadhesive patch; Ophthalmologic dosage form; Tailored medicine; 3D printing
资金
- Japan Society for the Promotion of Science [19K07170]
- Grants-in-Aid for Scientific Research [19K07170] Funding Source: KAKEN
3D printing technology has great potential in the pharmaceutical field. This study presents the fabrication of ophthalmologic patches using a 3D printer, which enables controlled drug release and personalized dosages.
3D printing technology is a novel and practical approach for producing unique and complex industrial and medical objects. In the pharmaceutical field, the approval of 3D printed tablets by the US Food and Drug Administration has led to other 3D printed drug formulations and dosage forms being proposed and investigated. Here, we report novel ophthalmologic patches for controlled drug release fabricated using a semi-solid material extrusion-type 3D printer. The patch-shaped objects were 3D printed using hydrogel-based printer inks composed of hypromellose (HPMC), sugar alcohols (mannitol, xylitol), and drugs, then freeze-dried. The viscous properties of the printer inks and patches were dependent on the HPMC and sugar alcohol concentrations. Then, the physical properties, surface structure, water uptake, antimicrobial activity, and drug release profile of lyophi-lized patches were characterized. Lyophilized ophthalmologic patches with different dosages and patterns were fabricated as models of personalized treatments prepared in hospitals. Then, ophthalmologic patches containing multiple drugs were fabricated using commercially available eye drop formulations. The current study indicates that 3D printing is applicable to producing novel dosage forms because its high flexibility allows the preparation of patient-tailored dosages in a clinical setting.
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