期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 622, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.121861
关键词
Discrete element method; Die filling; Flow behaviour; Stirrer speed; Filling ratio
资金
- Genentech Ltd.
- Engineering and Physical Science Research Council (EPSRC) [EP/M02976X]
- Marie Sklodowska-Curie Individual Fellowships under European Union's Horizon 2020 research and innovation programme [840264]
- Marie Curie Actions (MSCA) [840264] Funding Source: Marie Curie Actions (MSCA)
Understanding die filling behavior of powders is crucial for optimizing formulation and processes in industries like pharmaceuticals and fine chemicals. This study uses a graphics processing unit (GPU) based discrete element method (DEM) to analyze forced die filling with a powder feeder equipped with a wired stirrer. The study systematically explores the effects of operating parameters on die filling performance, such as initial powder bed height, filling speed, and stirrer speed.
Understanding die filling behaviour of powders is critical in developing optimal formulation and processes in various industries, such as pharmaceuticals and fine chemicals. In this paper, forced die filling is analysed using a graphics processing unit (GPU) based discrete element method (DEM), for which a powder feeder equipped with a wired stirrer is considered. The influences of operating parameters, such as the initial powder bed height, the filling speed, and the stirrer speed, on the die filling performance are systematically explored. It is shown that a larger initial powder bed height leads to a higher filling ratio, which can be attributed to a higher filling intensity; while the deposited particle mass in the die is almost independent of the powder bed height, when the initial fill level is larger than a critical bed height. Additionally, the filling ratio slightly increases with the increase of stirrer speed for cases with a stirrer, while the filling ratios are lower than that without a stirrer, which is attributed to the stirrer occupying some space above the die and reducing the effective discharge area. The obtained results can provide useful information for optimising the feeder system design and the operating condition.
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