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Exosomes as Promising Nanostructures in Diabetes Mellitus: From Insulin Sensitivity to Ameliorating Diabetic Complications

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Summary: Ageing is a significant risk factor for various degenerative diseases, affecting the senescence and function of Mesenchymal Stem Cells (MSCs) and their exosomes. Exosomes derived from aged MSCs exhibit accelerated biogenesis, altered cargoes, and reduced regenerative potential, potentially impacting recipient cell function negatively. Further research is required to elucidate the detailed mechanisms and translation of preclinical results into clinically relevant exosome therapies for combating ageing.

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