4.7 Review

Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis

期刊

出版社

MDPI
DOI: 10.3390/ijms23116046

关键词

bile acid; farnesoid X receptor; fibroblast growth factor 15; 19

资金

  1. Japan Society for the Promotion of Science KAKENHI [20K22746]
  2. Grants-in-Aid for Scientific Research [20K22746] Funding Source: KAKEN

向作者/读者索取更多资源

Bile acids have detergent and hormone-like properties. FXR and FGF15/19 are considered as potential therapeutic targets for metabolic syndrome and cholestatic diseases.
Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic side chain. While BAs act as detergents to solubilize lipophilic nutrients in the small intestine during digestion and absorption, they also act as hormones. Farnesoid X receptor (FXR) is a nuclear receptor that forms a heterodimer with retinoid X receptor alpha (RXR alpha), is activated by BAs in the enterohepatic circulation reabsorbed via transporters in the ileum and the colon, and plays a critical role in regulating gene expression involved in cholesterol, BA, and lipid metabolism in the liver. The FXR/RXR alpha heterodimer also exists in the distal ileum and regulates production of fibroblast growth factor (FGF) 15/FGF19, a hormone traveling via the enterohepatic circulation that activates hepatic FGF receptor 4 (FGFR4)-beta-klotho receptor complex and regulates gene expression involved in cholesterol, BA, and lipid metabolism, as well as those regulating cell proliferation. Agonists for FXR and analogs for FGF15/19 are currently recognized as a promising therapeutic target for metabolic syndrome and cholestatic diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据