期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms23105627
关键词
zyxin; ybx1; mRNA; nuclear receptor; retinoic acid; Xenopus; development
资金
- RFBR [20-34-90017]
- Ministry of Science and Higher Education of the Russian Federation [075-15-2021-1344]
Zyxin protein plays an important role in regulating the expression of maternal genes during early embryo development by affecting mRNA stability, especially in the regulation of retinoic acid signal pathway.
Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stemness factors of Pou5f3 family in Xenopus laevis embryos through binding to Y-box factor1. In the present work, we demonstrate that Zyxin can also affect mRNA stability of the maternally derived retinoid receptor Rxr gamma through the same mechanism. Moreover, we confirmed the functional link between Zyxin and Rxr gamma-dependent gene expression. As a result, Zyxin appears to play an essential role in the regulation of the retinoic acid signal pathway during early embryonic development. Besides, our research indicates that the mechanism based on the mRNA destabilization by Zyxin may take part in the control of the expression of a fairly wide range of maternal genes.
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