相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Cellular senescence as a source of SARS-CoV-2 quasispecies
Ioannis Karakasiliotis et al.
FEBS JOURNAL (2023)
Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
Laura Vangeel et al.
ANTIVIRAL RESEARCH (2022)
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
Pengfei Li et al.
CELL RESEARCH (2022)
A Review of the Current Landscape of SARS-CoV-2 Main Protease Inhibitors: Have We Hit the Bullseye Yet?
Guillem Macip et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease
Marina Macchiagodena et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2022)
The Battle between Host and SARS-CoV-2: Innate Immunity and Viral Evasion Strategies
Shilei Zhang et al.
MOLECULAR THERAPY (2022)
Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design
Brandon Malone et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)
Mechanisms of SARS-CoV-2 entry into cells
Cody B. Jackson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)
SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictions
Mariona Torrens-Fontanals et al.
NUCLEIC ACIDS RESEARCH (2022)
A structural view of the SARS-CoV-2 virus and its assembly
Nathan J. Hardenbrook et al.
CURRENT OPINION IN VIROLOGY (2022)
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
Yao Zhao et al.
PROTEIN & CELL (2022)
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir
Sven Ullrich et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets
Ali F. Alsulami et al.
BRIEFINGS IN BIOINFORMATICS (2021)
What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design
Muya Xiong et al.
MEDICINAL RESEARCH REVIEWS (2021)
Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource (vol 52, pg 999, 2020)
Stephanie Portelli et al.
NATURE GENETICS (2021)
N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease
Tomas Koudelka et al.
PROTEOMICS (2021)
Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management
Joseph Heskin et al.
LANCET (2021)
Repositioning HIV protease inhibitors and nucleos(t)ide RNA polymerase inhibitors for the treatment of SARS-CoV-2 infection and COVID-19
Nils von Hentig
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2021)
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Dafydd R. Owen et al.
SCIENCE (2021)
Screening of drug databank against WT and mutant main protease of SARS-CoV-2: Towards finding potential compound for repurposing against COVID-19
Tanuj Sharma et al.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19
Britton Boras et al.
NATURE COMMUNICATIONS (2021)
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome
Isabel Pablos et al.
CELL REPORTS (2021)
Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography
Daniel W. Kneller et al.
IUCRJ (2021)
Identification of mutation resistance coldspots for targeting the SARS-CoV2 main protease
Navaneethakrishnan Krishnamoorthy et al.
IUBMB LIFE (2021)
A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoV
Huan Zhou et al.
FRONTIERS IN MEDICINE (2021)
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study
Mohammad Hassan Baig et al.
MOLECULES (2021)
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection
Koen Vandyck et al.
CURRENT OPINION IN VIROLOGY (2021)
Virtual Alanine Scan of the Main Protease Active Site in Severe Acute Respiratory Syndrome Coronavirus 2
Tomoki Nakayoshi et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations
Bilal Ahmad et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
Elizabeth A. MacDonald et al.
ACS INFECTIOUS DISEASES (2021)
Cellular host factors for SARS-CoV-2 infection
Jim Baggen et al.
NATURE MICROBIOLOGY (2021)
SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants
Fengming Sun et al.
MICROBIOLOGY SPECTRUM (2021)
Coronavirus biology and replication: implications for SARS-CoV-2
Philip V'kovski et al.
NATURE REVIEWS MICROBIOLOGY (2021)
Transmitted drug resistance in newly diagnosed and treatment-naive HIV type 1-infected patients in Hungary
Eva Ay et al.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)
A new coronavirus associated with human respiratory disease in China
Fan Wu et al.
NATURE (2020)
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang et al.
SCIENCE (2020)
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin et al.
NATURE (2020)
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19
B. Cao et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease
Chunlong Ma et al.
CELL RESEARCH (2020)
Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease
Thomas J. Cross et al.
BIOCHEMISTRY (2020)
Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography
Daniel W. Kneller et al.
NATURE COMMUNICATIONS (2020)
Impact of Early Pandemic Stage Mutations on Molecular Dynamics of SARS-CoV-2 Mpro
Olivier Sheik Amamuddy et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main protease
Mohamed Mahdi et al.
VIROLOGY JOURNAL (2020)
Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society-USA Panel
Huldrych F. Gunthard et al.
CLINICAL INFECTIOUS DISEASES (2019)
Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs
Chinh Tran-To Su et al.
MOLECULES (2019)
Origin and evolution of pathogenic coronaviruses
Jie Cui et al.
NATURE REVIEWS MICROBIOLOGY (2019)
PDBsum: Structural summaries of PDB entries
Roman A. Laskowski et al.
PROTEIN SCIENCE (2018)
Multi-spectroscopic and molecular modeling approaches to elucidate the binding interaction between bovine serum albumin and darunavir, a HIV protease inhibitor
Jie-Hua Shi et al.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)
Data, disease and diplomacy: GISAID's innovative contribution to global health
Stefan Elbe et al.
GLOBAL CHALLENGES (2017)
Highly resistant HIV-1 proteases and strategies for their inhibition
Irene T. Weber et al.
FUTURE MEDICINAL CHEMISTRY (2015)
HIV-1 assembly, release and maturation
Eric O. Freed
NATURE REVIEWS MICROBIOLOGY (2015)
Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System
Mohamed Mahdi et al.
VIRUSES-BASEL (2015)
HIV infection
Steven G. Deeks et al.
NATURE REVIEWS DISEASE PRIMERS (2015)
Coronavirus infection, ER stress, apoptosis and innate immunity
To S. Fung et al.
FRONTIERS IN MICROBIOLOGY (2014)
The Prevalence of Transmitted Drug Resistance in Newly Diagnosed HIV-Infected Individuals in Croatia: The Role of Transmission Clusters of Men Who Have Sex with Men Carrying the T215S Surveillance Drug Resistance Mutation
Ivana Grgic et al.
AIDS RESEARCH AND HUMAN RETROVIRUSES (2013)
Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments
Luis Menendez-Arias
ANTIVIRAL RESEARCH (2013)
Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance
Madhavi N. L. Nalam et al.
CHEMISTRY & BIOLOGY (2013)
HIV Gag polyprotein: processing and early viral particle assembly
Neil M. Bell et al.
TRENDS IN MICROBIOLOGY (2013)
Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
Yunjeong Kim et al.
JOURNAL OF VIROLOGY (2012)
The structural biology of HIV-1: mechanistic and therapeutic insights
Alan Engelman et al.
NATURE REVIEWS MICROBIOLOGY (2012)
The origin of genetic diversity in HIV-1
Redmond P. Smyth et al.
VIRUS RESEARCH (2012)
HIV-1 Antiretroviral Drug Therapy
Eric J. Arts et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
HIV DNA Integration
Robert Craigie et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Ritonavir-boosted protease inhibitors in HIV therapy
Mark W. Hull et al.
ANNALS OF MEDICINE (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Accessory Mutations Maintain Stability in Drug-Resistant HIV-1 Protease
Max W. Chang et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses
Chi-Pang Chuck et al.
PLOS ONE (2011)
Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance
Annemarie M. J. Wensing et al.
ANTIVIRAL RESEARCH (2010)
Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
Shu-Chun Cheng et al.
BIOPHYSICAL JOURNAL (2010)
Profiling of Substrate Specificity of SARS-CoV 3CLpro
Chi-Pang Chuck et al.
PLOS ONE (2010)
Comparative Studies on Retroviral Proteases: Substrate Specificity
Jozsef Tozser
VIRUSES-BASEL (2010)
Molecular Basis for Drug Resistance in HIV-1 Protease
Akbar Ali et al.
VIRUSES-BASEL (2010)
Transmission of Drug-Resistant HIV-1 Is Stabilizing in Europe
Jurgen Vercauteren et al.
JOURNAL OF INFECTIOUS DISEASES (2009)
Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
Diane E. Bennett et al.
PLOS ONE (2009)
HIV-1 Protease: Structural Perspectives on Drug Resistance
Irene T. Weber et al.
VIRUSES-BASEL (2009)
Current and Novel Inhibitors of HIV Protease
Jana Pokorna et al.
VIRUSES-BASEL (2009)
Tipranavir resistance associated mutations in protease inhibitor-naive patients with HIV-1 subtype A/E infection
Somnuek Sungkanuparph et al.
JOURNAL OF CLINICAL VIROLOGY (2008)
HIV-1 protease inhibitors: effects on HIV-2 replication and resistance
Luis Menendez-Arias et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design
Xiaoyu Xue et al.
JOURNAL OF VIROLOGY (2008)
Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance
Arun K. Ghosh et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus
D. H. Goetz et al.
BIOCHEMISTRY (2007)
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004
Joris Hemelaar et al.
AIDS (2006)
The impact of transmitted drug resistance on the natural history of HIV infection and response to first-line therapy
D Pillay et al.
AIDS (2006)
In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease
AK Patick et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Coronavirus 3CLpro proteinase cleavage sites:: Possible relevance to SARS virus pathology -: art. no. 72
L Kiemer et al.
BMC BIOINFORMATICS (2004)
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
M Prabu-Jeyabalan et al.
JOURNAL OF VIROLOGY (2004)
Human immunodeficiency virus reverse transcriptase and protease sequence database
SY Rhee et al.
NUCLEIC ACIDS RESEARCH (2003)
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
M Prabu-Jeyabalan et al.
STRUCTURE (2002)
Resistance to protease inhibitors
V Miller
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2001)
Implications of antiretroviral resistance on viral fitness
M Nijhuis et al.
CURRENT OPINION IN INFECTIOUS DISEASES (2001)
Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples
K Hertogs et al.
AIDS (2000)