期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms23084244
关键词
sphingolipids; glomerular diseases; tubulointerstitial diseases
资金
- National Institutes of Health [R01DK117599, R01DK104753, R01CA227493]
- Miami Clinical Translational Science Institute [U54DK083912, UM1DK100846, U01DK116101, UL1TR000460]
Sphingolipids play important roles in cellular processes and abnormalities are associated with kidney diseases. Understanding the regulation of sphingolipid signaling in kidney diseases can lead to the development of therapeutics.
Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. This review summarizes the studies in our understanding of the regulation of sphingolipid signaling in kidney diseases, especially in glomerular and tubulointerstitial diseases, and the potential to target sphingolipid pathways in developing therapeutics for the treatment of renal diseases.
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