NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs' biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs' properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.

Automated summary

This review focuses on coordination compounds with first-row transition metals, such as copper, cobalt, nickel, manganese, or zinc, and their potential pharmacological properties. Metal complexes have been found to enhance the biological activities of drugs, such as anticancer, antimicrobial, or anti-inflammatory effects. The review also highlights the research on complexes of first-row transition metals and nonsteroidal anti-inflammatory drugs (NSAIDs) and their promising or effective results.