Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

Automated summary

Non-melanoma skin cancers, primarily basal cell carcinomas and squamous cell carcinomas, are the most common form of cancer in the US. The increasing incidence of squamous cell carcinomas leads to significant morbidity and rising treatment costs, exceeding one billion dollars annually. Research on the molecular basis and development of squamous cell carcinomas aims to provide new insights into pathogenesis and drive the development of cost-effective and low morbidity therapies.