期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms23116024
关键词
drug resistance; Streptococcus dysgalactiae; AgNPs; efflux effect; translational research
资金
- CONACYT, Mexico [1073]
- Tomsk Polytechnic University Development Program Priority 2030 by Tomsk Polytechnic University, Russia
This study examines the use of silver nanoparticles (AgNPs) to address antibiotic resistance. The findings demonstrate that treating mastitis in cows with Argovit-C (TM) AgNPs can enhance antibiotic sensitivity, while treatment with antibiotic drugs like Spectromast LC and Lactobay increase bacterial resistance. These results have important implications for preserving the wide spectrum of antibiotics on the market.
The present work is a continuation of our translational research focusing on the use of silver nanoparticles (AgNPs) to solve the global problem of antibiotic resistance. In vivo fieldwork was done with 300 breeding farm cows with serous mastitis. Ex vivo assays revealed that after cow treatment with the antibiotic drug Spectromast LC (TM), S. dysgalactiae susceptibility to 31 antibiotics dropped by 22.9%, but after treatment with Argovit-C (TM) AgNPs, it was raised by 13.1%. This was explained by the fact that the percentage of isolates with an efflux effect after Spectromast LC treatment resulted in an 8% increase, while Argovit-C-treatment caused a 19% decrease. The similarity of these results to our previous results on S. aureus isolates from mastitis cows treated with the antibiotic drug Lactobay and Argovit-C (TM) AgNPs was shown. So, mastitis treatments with Argovit-C (TM) AgNPs can partially return the activity of antibiotics towards S. dysgalactiae and S. aureus, while, in contrast, treatments with antibiotic drugs such as Spectromast LC and Lactobay enhance bacterial resistance to antibiotics. The results of this work strengthen the hope that in the future the use of AgNPs as efflux pump inhibitors will recover the activity of antibiotics, and thus will preserve the wide spectrum of antibiotics on the market.
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