Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity

The dynamic balance of mitochondrial fission and fusion maintains mitochondrial homeostasis and optimal function. It is indispensable for cells such as neurons, which rely on the finely tuned mitochondria to carry out their normal physiological activities. The potent psychostimulant cocaine impairs mitochondria as one way it exerts its neurotoxicity, wherein the disturbances in mitochondrial dynamics have been suggested to play an essential role. In this review, we summarize the neurotoxicity of cocaine and the role of mitochondrial dynamics in cellular physiology. Subsequently, we introduce current findings that link disturbed neuronal mitochondrial dynamics with cocaine exposure. Finally, the possible role and potential therapeutic value of mitochondrial dynamics in cocaine neurotoxicity are discussed.

Automated summary

This review discusses the neurotoxic effects of cocaine and the role of mitochondrial dynamics in cellular physiology. It highlights how cocaine can disrupt neuronal mitochondrial dynamics and impair cellular function. Understanding and studying the relationship between mitochondrial dynamics and cocaine exposure is crucial for exploring the mechanisms of cocaine neurotoxicity and potential therapeutic interventions.