☆ 4.7 Editorial Material

Curcumin 3.0-Therapeutic and Diagnostic Potential in Cancer and Beyond

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-kappa B Inhibitors

Mohamed E. M. Saeed et al.

Summary: This study evaluated the binding affinities of 50 curcumin derivatives to cancer-related target proteins EGFR and NF-kappa B using a molecular docking approach. The results showed similar binding affinities of the curcumin compounds for both target proteins. In silico results were validated using microscale thermophoresis, and bioactivity was further investigated through various assays. The study suggests that the derivatization of curcumin may be a promising strategy to develop more effective targeted curcumin-based drugs for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature

Eslam El Nebrisi

Summary: Parkinson's disease is a slowly progressive disorder affecting dopaminergic neurons, and the treatment with levodopa often leads to unwanted dyskinesia. The discovery of new therapeutic approaches to slow down or reverse neurodegeneration in PD is a crucial unmet need. Curcumin as a potential therapeutic agent for PD has neuroprotective activities, while alpha 7-nAChR is proposed as a potential therapeutic approach in PD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Sodium Butyrate Enhances Curcuminoids Permeability through the Blood-Brain Barrier, Restores Wnt/β-Catenin Pathway Antagonists Gene Expression and Reduces the Viability of Glioblastoma Cells

Aleksandra Majchrzak-Celinska et al.

Summary: This study demonstrates that curcuminoids and sodium butyrate synergistically reduce the viability of glioblastoma cells by inducing apoptosis and cell cycle arrest, with these effects mediated through reactive oxygen species generation and changes in gene expression. Additionally, sodium butyrate improves the permeability of curcuminoids through the blood-brain barrier and nasal cavity, indicating that they are promising agents with anti-glioblastoma properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Metal-Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin

Sahdeo Prasad et al.

Summary: Curcumin, an active compound in turmeric, has various pharmacological properties, but its effectiveness is limited by its nature. Metal-curcumin complexes have been developed to enhance solubility and absorption, showing positive effects against chronic diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers Following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma

Daniel L. Pouliquen et al.

Summary: The study identified proteomic changes induced by curcumin treatment in a rat model of malignant mesothelioma, revealing a list of proteins associated with anticancer therapeutic effects and common biomarkers in different lymphoid organs. These findings suggest potential systemic, non-target antitumor effects of curcumin at a molecular level.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry

Matteo Mari et al.

Summary: Curcumin and its derivatives are studied as potential radiotracers for early diagnosis of Alzheimer's disease and cancer, with chemical modifications and functionalization enhancing stability and labelling efficiency.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Curcumin Loaded PEGylated Nanoemulsions Designed for Maintained Antioxidant Effects and Improved Bioavailability: A Pilot Study on Rats

Jelena B. Dokovic et al.

Summary: The experimental design- guided development of PEGylated nanoemulsions as a parenteral delivery system for curcumin resulted in stable physicochemical characteristics and antioxidant activity after two years of storage. The nanoemulsion carrier demonstrated safe and effective delivery of curcumin, with improved plasma residence time compared to non-PEGylated nanoemulsions or curcumin solution.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Growth, Proliferation and Metastasis of Prostate Cancer Cells Is Blocked by Low-Dose Curcumin in Combination with Light Irradiation

Jochen Rutz et al.

Summary: Combining curcumin with visible light irradiation significantly suppresses tumor growth, adhesion, and migration in prostate cancer cells in vitro, potentially by reducing the expression of cell cycle regulating proteins and integrins.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Jeffersson Krishan Trigo-Gutierrez et al.

Summary: Curcumin (CUR) is a natural substance with antimicrobial properties extracted from turmeric. To overcome its limitations in clinical use, drug delivery systems (DDSs) have been used to carry CUR effectively against various pathogens.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carcinoma Metastatic Behavior in Vitros

Jochen Rutz et al.

CANCERS (2020)

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Article Oncology

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

Peter H. Killian et al.

CARCINOGENESIS (2012)

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Article Cell Biology

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice

Beatrice E. Bachmeier et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)

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