The Role of Vitamin D in Supporting Health in the COVID-19 Era

Article Nutrition & Dietetics

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients

Sreedhar Subramanian et al.

Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

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Article Endocrinology & Metabolism

A randomized pilot study using calcitriol in hospitalized COVID-19 patients

Yasmine M. Elamir et al.

Summary: A trial investigating the use of calcitriol in hospitalized COVID-19 patients showed improvement in oxygenation and higher percentage of patients discharged without needing oxygen supplementation in the calcitriol group. Additionally, patients in the calcitriol group had shorter hospital stays. These results suggest potential benefits of calcitriol therapy and support the need for larger randomized trials.

BONE (2022)

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Review Endocrinology & Metabolism

Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis

Harsha Anuruddhika Dissanayake et al.

Summary: Multiple observational studies involving nearly 2 million adults suggest that vitamin D deficiency/insufficiency increases susceptibility to COVID-19 and severe COVID-19, although with a high risk of bias and heterogeneity. Association with mortality was less robust. Heterogeneity in RCTs precluded their meta-analysis.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Health Care Sciences & Services

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality

Karen H. Seal et al.

Summary: This study aims to investigate the relationship between vitamin D status and COVID-19-related clinical outcomes. The results show a significant inverse dose-response relationship between continuous 25(OH)D concentrations and COVID-19-related hospitalization and mortality after adjusting for factors associated with both vitamin D deficiency and COVID-19 outcomes.

JOURNAL OF GENERAL INTERNAL MEDICINE (2022)

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Article Nutrition & Dietetics

Vitamin D deficiency in critically ill COVID-19 ARDS patients

Quirin Notz et al.

Summary: Vitamin D deficiency is common in COVID-19 ARDS patients. While 25-hydroxyvitamin D status is not related to clinical course changes, low levels of 1,25-dihydroxyvitamin D are associated with prolonged mechanical ventilation and a worse APACHE II score.

CLINICAL NUTRITION (2022)

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Article Nutrition & Dietetics

A critical update on the role of mild and serious vitamin D deficiency prevalence and the COVID-19 epidemic in Europe

Dimitra Rafailia Bakaloudi et al.

Summary: This study found no significant correlation between prevalence of both mild and severe Vitamin D deficiency with COVID-19 infections in European countries. However, a significant correlation was observed between Vitamin D deficiency and COVID-19 mortality.

NUTRITION (2022)

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Article Multidisciplinary Sciences

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

Amiel A. Dror et al.

Summary: This study found that pre-infection deficiency of vitamin D is associated with increased disease severity and mortality in hospitalized COVID-19 patients.

PLOS ONE (2022)

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Article Immunology

Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?

Federica Saponaro et al.

Summary: This study investigated the relationship between vitamin D levels and inflammatory markers in COVID-19 patients. The findings suggest that hypovitaminosis D is associated with higher levels of inflammatory markers and is related to disease severity and prognosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

A large-scale computational screen identifies strong potential inhibitors for disrupting SARS-CoV-2 S-protein and human ACE2 interaction

Adarsh Singh et al.

Summary: SARS-CoV-2 has infected millions of people worldwide, leading to over 2.7 million deaths. While vaccines have been introduced, the rapid decline of antibodies could reduce their efficacy, highlighting the need for effective drugs against COVID-19.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Biochemistry & Molecular Biology

Vitamin D3 and its hydroxyderivatives as promising drugs against COVID-19: a computational study

Yuwei Song et al.

Summary: The study suggests that vitamin D3 and its hydroxyderivatives could serve as TMPRSS2 inhibitors and inhibit the binding of ACE2 to SARS-CoV-2 RBD to prevent viral entry. Interaction of 1,25(OH)2D3 with SARS-CoV-2 RBD and ACE2 results in conformational changes that interrupt their binding.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Endocrinology & Metabolism

Vitamin D supplementation and COVID-19 risk: a population-based, cohort study

J. Oristrell et al.

Summary: In this large population-based study, it was observed that supplementation with cholecalciferol or calcifediol leading to serum 25OHD levels >= 30 ng/ml was associated with better COVID-19 outcomes.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Article Critical Care Medicine

Vitamin D Status and Clinical Outcomes in Acute Respiratory Distress Syndrome: A Secondary Analysis From the Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury (ALVEOLI) Trial

Sadeq A. Quraishi et al.

Summary: The study found that in ARDS patients, vitamin D levels are associated with duration of mechanical ventilation and 90-day mortality. Patients with lower 25OHD levels had longer ventilation time and higher risk of mortality. Randomized, controlled trials are needed to determine if vitamin D supplementation can improve clinical outcomes in ARDS patients.

JOURNAL OF INTENSIVE CARE MEDICINE (2022)

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Article Medicine, General & Internal

Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)

Ashu Rastogi et al.

Summary: This study investigates the effect of high-dose oral cholecalciferol supplementation on SARS-CoV-2 viral clearance. The results show that supplementation with cholecalciferol can increase the proportion of vitamin D-deficient individuals who become SARS-CoV-2 RNA negative and reduce fibrinogen levels.

POSTGRADUATE MEDICAL JOURNAL (2022)

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Article Endocrinology & Metabolism

Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19

G. E. Carpagnano et al.

Summary: This study analyzed vitamin D levels in patients with acute respiratory failure due to COVID-19 and found a high prevalence of hypovitaminosis D, with severe deficiency associated with significantly higher mortality risk. Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Article Medicine, General & Internal

Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis

J. M. Rhodes et al.

Summary: There is substantial evidence supporting a link between vitamin D deficiency and COVID-19 severity, although the evidence is indirect. Community-based placebo-controlled trials of vitamin D supplementation may be challenging, but further evidence may come from large cohort studies with prescribing data or serum 25(OH) vitamin D level assays. In the meantime, vitamin D supplementation is strongly recommended for individuals at risk of deficiency.

JOURNAL OF INTERNAL MEDICINE (2021)

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Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Virology

Vitamin D insufficiency as a potential culprit in critical COVID-19 patients

Ruhul Munshi et al.

Summary: The study suggests that serum vitamin D levels may be associated with the prognosis of COVID-19. Diagnosis of vitamin D deficiency could assist in assessing patients' potential for developing severe COVID-19, and appropriate preventative and/or therapeutic interventions may improve COVID-19 outcomes.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Nutrition & Dietetics

Serum level of vitamin D as a predictor for severity and outcome of pneumonia

Tarik Saber Sarhan et al.

Summary: The study demonstrates a high prevalence of vitamin D deficiency among pneumonia patients, with deficient individuals showing higher disease severity and complication rates. Furthermore, there is a correlation between vitamin D levels and the severity and outcomes of pneumonia.

CLINICAL NUTRITION (2021)

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Article Medicine, Research & Experimental

Vitamin D Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in A549 Cells by Downregulating Inflammatory Cytokines

Vesara A. Gatera et al.

Summary: Vitamin D has the potential to promote cell survival following inflammation induced by LPS by down regulating inflammatory cytokines in A549 cells, suggesting it may be effective in managing lung inflammation. Further studies are needed to confirm these results.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2021)

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Review Infectious Diseases

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Stephany Beyerstedt et al.

Summary: ACE2 plays a crucial role in COVID-19, with its expression potentially having paradoxical effects, aiding SARS-CoV-2 pathogenicity while also limiting viral infection.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Letter Cardiac & Cardiovascular Systems

Vitamin D deficiency correlates with a reduced number of natural killer cells in intensive care unit (ICU) and non-ICU patients with COVID-19 pneumonia

Alice G. Vassiliou et al.

HELLENIC JOURNAL OF CARDIOLOGY (2021)

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Article Immunology

Low Vitamin D Status Is Associated with Inflammation in Patients with Chronic Obstructive Pulmonary Disease

Lin Fu et al.

Summary: Vitamin D deficiency is associated with increased inflammation in COPD patients. As the severity of COPD worsens, serum 25(OH)D levels gradually decrease. Activation of NF-kappa B and AP-1 signaling pathways is observed in COPD patients.

JOURNAL OF IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

Treatment With 25-Hydroxyvitamin D3 (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-to-Lymphocyte Ratio Marker of Disease Severity in Hospitalized Patients With COVID-19: A Pilot Multicenter, Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

Zhila Maghbooli et al.

Summary: The study demonstrated that oral 25(OH)D3 corrected vitamin D deficiency/insufficiency in COVID-19 patients, leading to improved immune function by increasing lymphocyte counts. This treatment was associated with reduced intensive care unit admission days and mortality.

ENDOCRINE PRACTICE (2021)

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Review Biochemistry & Molecular Biology

Dysregulation of Cell Signaling by SARS-CoV-2

Rahul K. Suryawanshi et al.

Summary: SARS-CoV-2 infection manipulates host pathways, reorganizes host cell structure, impairs innate cellular defenses, and induces delayed hyperinflammation while weakening interferon response. Understanding the complex interactions between SARS-CoV-2 and host signaling pathways provides crucial strategic clues for the development of novel therapeutics.

TRENDS IN MICROBIOLOGY (2021)

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Article Nutrition & Dietetics

Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study

Sandro Giannini et al.

Summary: This retrospective study aimed to examine the clinical outcome of hospitalized COVID-19 patients receiving high-dose cholecalciferol treatment. The study found that the therapeutic effect of vitamin D treatment on COVID-19 patients may be significantly impacted by the burden of comorbidities.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

Cedric Annweiler et al.

Summary: The study found that supplementation of vitamin D3 prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19. The intervention group had a significantly higher survival rate at 3 months compared to the comparator group, with a lower hazard ratio for 3-month mortality.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Review Cell Biology

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients

Malgorzata Kloc et al.

Summary: Vitamin D plays a crucial role in regulating homeostasis, immune response, and inflammation. Vitamin D deficiency can worsen the severity of ARDS in COVID-19 infection, while supplementation may help alleviate ARDS symptoms by influencing inflammatory response in macrophages and MDSCs.

CELLULAR IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19

George Griffin et al.

Summary: Recent studies have shown that high-dose intermittent bolus vitamin D therapy is ineffective at preventing rickets, and low dose daily maintenance is recommended instead. The well-documented associations between COVID-19 risk and vitamin D deficiency make this particularly important during the current pandemic.

CLINICAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System

Sicheng Zhang et al.

Summary: Vitamin D plays a crucial role in human health, not only in the musculoskeletal system but also in other areas. Deficiency of vitamin D is associated with various diseases, including osteoporosis, cardiovascular diseases, and cancer. More research is needed to assess the role of vitamin D in optimizing health and preventing diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial

Igor H. Murai et al.

Summary: The study found that a single high dose of vitamin D-3 did not significantly reduce hospital length of stay among hospitalized patients with COVID-19. The findings do not support the use of a high dose of vitamin D-3 for treatment of moderate to severe COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Biochemistry & Molecular Biology

Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection

Mobeen Abdrabbo et al.

Summary: Recent studies suggest that Vitamin D supplementation can reduce oxidative stress, potentially benefitting in preventing COVID-19 infection. However, the relationship between Vitamin D deficiency, oxidative stress, and the severity of COVID-19 remains unclear.

PROTEIN SCIENCE (2021)

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Article Nutrition & Dietetics

Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

Alberto Sulli et al.

Summary: The study demonstrates that vitamin D deficiency in COVID-19 patients is associated with severe lung involvement, longer disease duration, and higher risk of death, particularly in elderly patients. Low vitamin D levels are negatively correlated with the severity of radiologic pulmonary involvement.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1

Mustafa Sait Gonen et al.

Summary: The study found that vitamin D treatment in COVID-19 patients can significantly increase serum vitamin D levels, shorten hospital stays, and reduce mortality. Vitamin D supplementation may work by regulating specific biomarkers.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients

Carlos Loucera et al.

Summary: A study on 15,968 COVID-19 patients in Andalusia found a stronger association between prescription of vitamin D (metabolites) and patient survival when prescribed 15 days prior to hospitalization compared to 30 days. Calcifediol showed a stronger association than cholecalciferol.

SCIENTIFIC REPORTS (2021)

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Article Dermatology

Ultraviolet A radiation and COVID-19 deaths in the USA with replication studies in England and Italy

M. Cherrie et al.

Summary: Research indicates that higher ambient UVA exposure is associated with lower COVID-19-specific mortality, suggesting potential population health benefits and novel treatments.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Pediatrics

The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital

Elvan Bayramoglu et al.

Summary: This study investigated the relationship between vitamin D levels and clinical severity as well as inflammation markers in children and adolescents with COVID-19. The results showed that vitamin D deficiency was associated with higher clinical severity and inflammation markers, suggesting a potential role of vitamin D in modulating the systemic inflammatory response in pediatric COVID-19 cases.

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Article Biochemistry & Molecular Biology

Vitamin D and Beta-Glucans Synergically Stimulate Human Macrophage Activity

Loredana Bergandi et al.

Summary: The combined treatment with vitamin D and beta-glucans was found to enhance the immunomodulatory properties of human macrophages, leading to increased cytokine production, intracellular vesicle acidification, and changes in energy metabolism. These results suggest a novel therapeutic approach using the synergy between the two natural compounds to boost the immune response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

The Effects of Vitamin D on Immune System and Inflammatory Diseases

Tomoka Ao et al.

Summary: Vitamin D plays a crucial role in immune cells and has anti-inflammatory effects. Deficiency in vitamin D is associated with infectious diseases and autoimmune diseases, though its impact on treatment and prevention remains controversial.

BIOMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Vitamin D and its therapeutic relevance in pulmonary diseases

Shaniya Ahmad et al.

Summary: Vitamin D plays a key role in various cellular processes and has been associated with maintaining bone and calcium homeostasis, as well as regulating host defense, immunity, and inflammation. Studies have shown correlations between vitamin D deficiency and progression of lung disorders, although the underlying mechanism remains unclear. Vitamin D has inhibitory effects on pulmonary inflammation and enhances innate immune defenses through influencing multiple inflammatory cells.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Virology

A Strong Seasonality Pattern for Covid-19 Incidence Rates Modulated by UV Radiation Levels

Christos Karapiperis et al.

Summary: The study found that UV radiation is strongly associated with Covid-19 incidence rates, more so than mobility, making it a key indicator for seasonality. The findings can inform public health emergency measures based on seasons in the Northern and Southern Hemispheres.

VIRUSES-BASEL (2021)

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Review Nutrition & Dietetics

Vitamin D Review: The Low Hanging Fruit for Human Health

Lucy N. W. Mungai et al.

Summary: Vitamin D plays a crucial role in regulating calcium and phosphate metabolism, affecting not only bone and teeth health but also various biological processes such as cell growth, immune regulation, and DNA stability. Despite being synthesized in the body through sunlight exposure, many individuals still have low levels of vitamin D, highlighting the importance of understanding how it functions in the body.

JOURNAL OF NUTRITION AND METABOLISM (2021)

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Article Multidisciplinary Sciences

Climate and the spread of COVID-19

Simiao Chen et al.

Summary: The visual inspection of global maps indicates that COVID-19 is less prevalent in countries closer to the equator due to higher temperatures and humidity. Regression analysis shows that countries closer to the equator can expect fewer cases per million inhabitants, with a decline in cases expected during summer. However, this does not suggest that the virus will vanish in summer, but rather higher temperatures and UV radiation may support public health measures to contain the virus.

SCIENTIFIC REPORTS (2021)

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Article Endocrinology & Metabolism

No association between vitamin D status and COVID-19 infection in Sao Paulo, Brazil

Cynthia M. Alvares Brandao et al.

Summary: The study found no association between 25(OH)D levels and susceptibility to COVID-19 in the specific population studied and suggested that clinical, environmental, socioeconomic, and cultural factors may play a greater role in determining susceptibility to the infection.

ARCHIVES OF ENDOCRINOLOGY METABOLISM (2021)

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Article Medicine, Research & Experimental

Intravenous calcitriol administration regulates the renin-angiotensin system and attenuates acute lung injury in obese mice complicated with polymicrobial sepsis

Chiu-Li Yeh et al.

Summary: Calcitriol treatment post-sepsis induction upregulated RAS-associated anti-inflammatory pathway and decreased immune cell infiltration, alleviating severity of ALI in obese mice.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cardiac & Cardiovascular Systems

A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19

Luiza Szarpak et al.

Summary: This meta-analysis found that low serum vitamin D levels are significantly associated with the risk of COVID-19 infection, especially in the deficiency risk groups where supplementation of vitamin D is indicated.

CARDIOLOGY JOURNAL (2021)

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Article Nutrition & Dietetics

The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study

Mehmet Guven et al.

Summary: This study aimed to investigate the relationship between clinical course and inhospital mortality with high-dose vitamin D-3 administration within the first 24 hours of admission for COVID-19 ICU patients with vitamin D deficiency. The results showed that parenteral administration of high-dose vitamin D-3 did not reduce the need for intubation, length of hospital stay, and inhospital mortality in critically ill COVID-19 patients with vitamin D deficiency.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

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Article Endocrinology & Metabolism

Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial

Jose Luis Perez-Castrillon et al.

Summary: This study confirms the efficacy of calcifediol compared to cholecalciferol in raising serum 25-hydroxyvitamin D levels, presenting itself as a faster and more potent option for the treatment of vitamin D deficiency.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

The relationship between 25(OH) vitamin D levels and COVID-19 onset and disease course in Spanish patients

Manuel Diaz-Curiel et al.

Summary: This study aimed to investigate the relationship between vitamin D levels and disease severity in COVID-19 patients, with findings showing that hospitalized patients often had lower levels of 25(OH)D, while male and older patients were more likely to be admitted to the ICU. The study also revealed an independent association between vitamin D levels and ICU admission rates.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

Fausto Petrelli et al.

Summary: Vitamin D plays a protective role by modulating the immune system and systemic inflammatory response, reducing the risk and severity of COVID-19 infection. Patients with deficient vitamin D levels are more likely to be infected with COVID-19, and are more likely to experience severe symptoms and death.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Multidisciplinary Sciences

Vitamin D deficiency and severity of pneumonia in Indonesian children

Vicka Oktaria et al.

Summary: The study found that one in every five children hospitalized with pneumonia in Indonesia was vitamin D deficient. Vitamin D status was not significantly associated with the severity of pneumonia in these children, however, factors such as age younger than 6 months, low birth weight, and poor nutritional status on admission were associated with prolonged hospitalization and risk of hypoxemia.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

Bindu D. Paul et al.

Summary: The review summarizes evidence of biological abnormalities in patients with acute COVID-19 and ME/CFS, including redox imbalance, systemic inflammation, neuroinflammation, impaired ATP generation, and general hypometabolism. Although these phenomena have not been extensively studied in individuals with long COVID-19, understanding these abnormalities may lead to the development of novel therapeutics.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Nutrition & Dietetics

Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection

Liam Townsend et al.

Summary: A study investigated the relationship between vitamin D and persistent fatigue and reduced exercise tolerance following COVID-19, but found no association between the two.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study

Juan F. Alcala-Diaz et al.

Summary: A study in five hospitals in the South of Spain found that COVID-19 patients who received oral calcifediol treatment had significantly lower in-hospital mortality during the first 30 days compared to those who did not receive the treatment.

NUTRIENTS (2021)

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Article Nutrition & Dietetics

Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

Shaun Sabico et al.

Summary: The study demonstrated that daily supplementation of 5000 IU vitamin D3 for two weeks significantly increased serum 25(OH)D levels. Additionally, the 5000 IU group had a shorter recovery time for cough and loss of taste compared to the 1000 IU group.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank

Xue Li et al.

Summary: While no significant association between vitamin D levels and COVID-19 infection risk was found, a strong inverse relationship was observed between ambient UVB radiation and COVID-19 hospitalization and death rates. Additionally, genetically-predicted vitamin D levels showed a greater protective effect in stronger ambient UVB radiation. Further studies are needed to confirm the potential benefits of vitamin D supplementation in protecting against severe COVID-19 outcomes.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

被撤回的出版物: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease (Retracted article. See vol. 12, 2022)

Maheshwar Lakkireddy et al.

Summary: This study investigated the impact of Pulse D therapy on reducing inflammatory markers of COVID-19. The results showed a significant reduction in inflammatory markers in the VD group after receiving Pulse D therapy, while the reduction in the NVD group was not significant.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Solar UV-B/A radiation is highly effective in inactivating SARS-CoV-2

Fabrizio Nicastro et al.

Summary: The study shows that UV-B/A photons have a strong virucidal effect and can quickly inactivate the Covid-19 virus. Solar radiation intensity plays a significant role in virus transmission, helping to plan epidemic control strategies.

SCIENTIFIC REPORTS (2021)

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Article Orthopedics

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

Cun Zhang et al.

Summary: Vitamin D can attenuate TNF-alpha-induced apoptosis of human nucleus pulposus cells through interfering with the NF-kappa B pathway, as observed in gene expression data analysis.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Review Endocrinology & Metabolism

Vitamin D: Bolus Is Bogus-A Narrative Review

Richard B. Mazess et al.

Summary: This review summarizes the impact of high bolus doses versus daily doses of vitamin D on levels of 25(OH)D and 1,25(OH)(2)D, as well as on factors blocking vitamin D functions. It also discusses the role of bolus versus daily dosing of vitamin D in various health outcomes, highlighting potential biases in health recommendations based on different dosing trials.

JBMR PLUS (2021)

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Review Biochemistry & Molecular Biology

Vitamin D and COVID-19: An Overview of Recent Evidence

Drishti Ghelani et al.

Summary: The role of vitamin D in modulating the immune system in the context of COVID-19 has been discussed in research, with evidence suggesting that low levels of vitamin D may lead to poor prognosis but supplementation can help mitigate these effects, although its benefits remain controversial.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Endocrinology & Metabolism

The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality

Prakash Acharya et al.

Summary: In this study, treatment with vitamin D in patients with vitamin D deficiency and no prior history of myocardial infarction significantly reduced the risk of myocardial infarction and all-cause mortality. Maintaining vitamin D levels above 30 ng/mL was associated with a more significant reduction in the risk of myocardial infarction.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

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Article Geriatrics & Gerontology

Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective case-control study in an Arab Gulf country

Abdullah M. Alguwaihes et al.

Summary: This retrospective case-control study found that vitamin D deficiency is not associated with SARS-CoV-2 infection in hospitalized patients, but severe deficiency may increase the risk of mortality. More clinical trials are needed to determine if correcting vitamin D status can provide protective effects against severe outcomes of COVID-19.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2021)

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Article Pediatrics

Relationship Between Serum Vitamin D Levels and Acute Pneumonia in Children Aged 1-59 Months in Nigeria

Festus Dele Akeredolu et al.

Summary: This study in Nigeria found that low serum vitamin D levels were associated with an increased risk of acute pneumonia in children under 5 years old. Higher serum 25(OH)D levels were linked to a decreased odds of acute pneumonia after adjusting for confounders.

JOURNAL OF TROPICAL PEDIATRICS (2021)

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Article Endocrinology & Metabolism

The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality

Prakash Acharya et al.

Summary: For patients with Vitamin D deficiency and no prior history of myocardial infarction, treatment to reach 25-hydroxyvitamin D levels above 20 ng/mL and 30 ng/mL is associated with significantly lower risk of all-cause mortality. The lower risk of myocardial infarction is only observed in individuals maintaining 25-OH levels above or equal to 30 ng/mL.

JOURNAL OF THE ENDOCRINE SOCIETY (2021)

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Review Cell Biology

Mitochondrial Functions in Infection and Immunity

Varnesh Tiku et al.

TRENDS IN CELL BIOLOGY (2020)

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Review Nutrition & Dietetics

A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection

Adrian F. Gombart et al.

NUTRIENTS (2020)

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Article Critical Care Medicine

COVID-19 with Different Severities: A Multicenter Study of Clinical Features

Yun Feng et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Editorial Material Immunology

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

Toshio Hirano et al.

IMMUNITY (2020)

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Article Nutrition & Dietetics

Key Vitamin D Target Genes with Functions in the Immune System

Oona Koivisto et al.

NUTRIENTS (2020)

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Review Nutrition & Dietetics

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

William B. Grant et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

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Article Cell Biology

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

Keshav K. Singh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

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Article Medicine, General & Internal

Can a Combination of AT1R Antagonist and Vitamin D Treat the Lung Complication of COVID-19?

Mohamed Rafiullah

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2020)

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Review Endocrinology & Metabolism

Vitamin D and COVID-19

John P. Bilezikian et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

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Article Biochemistry & Molecular Biology

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study

Eugene Merzon et al.

FEBS JOURNAL (2020)

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Article Medicine, Research & Experimental

Neutrophil extracelluar traps in COVID-19

Yu Zuo et al.

JCI INSIGHT (2020)

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Article Biochemistry & Molecular Biology

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells

Gennadi Glinsky

BIOMEDICINES (2020)

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Article Public, Environmental & Occupational Health

Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank

Zahra Raisi-Estabragh et al.

JOURNAL OF PUBLIC HEALTH (2020)

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Article Endocrinology & Metabolism

Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study

Bess Dawson-Hughes et al.

DIABETES CARE (2020)

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Article Pharmacology & Pharmacy

Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-κB pathway

Giovanni Cimmino et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Nutrition & Dietetics

Immunologic Effects of Vitamin D on Human Health and Disease

Nipith Charoenngam et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Vitamin D and survival in COVID-19 patients: A quasi-experimental study

Cedric Annweiler et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study

Marta Entrenas Castillo et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels

Harvey W. Kaufman et al.

PLOS ONE (2020)

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Review Biochemistry & Molecular Biology

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

Natalia de las Heras et al.

ANTIOXIDANTS (2020)

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Article Biochemistry & Molecular Biology

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

Sourish Ghosh et al.

CELL (2020)

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Article Nutrition & Dietetics

Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort

Alice G. Vassiliou et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study

Stephanie F. Ling et al.

NUTRIENTS (2020)

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Article Nutrition & Dietetics

Vitamin D deficiency as the risk of respiratory tract infections in the institutionalized elderly: A prospective 1-year cohort study

Akiko Kuwabara et al.

CLINICAL NUTRITION ESPEN (2020)

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Article Nutrition & Dietetics

Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)

Chuen Wen Tan et al.

NUTRITION (2020)

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Article Endocrinology & Metabolism

Vitamin D concentrations and COVID-19 infection in UK Biobank

Claire E. Hastie et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Review Critical Care Medicine

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Wentao Ni et al.

CRITICAL CARE (2020)

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Article Immunology

Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial

Amrollah Sharifi et al.

APMIS (2019)

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Article Cell Biology

Vitamin D downregulates key genes of diabetes complications in cardiomyocyte

Hoda Derakhshanian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Review Endocrinology & Metabolism

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

Dimitra Zisi et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2019)

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Article Biochemistry & Molecular Biology

Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health

Chiara Ricca et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Biochemistry & Molecular Biology

Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species

Brandon J. Berry et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

The concept of the personal vitamin D response index

Carsten Carlberg et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

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Article Multidisciplinary Sciences

Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations >= 60 vs < 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort

Sharon L. McDonnell et al.

PLOS ONE (2018)

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Review Biochemistry & Molecular Biology

Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications

Mayte Medrano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Oncology

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system

Jun Xu et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Biochemistry & Molecular Biology

Cathelicidins display conserved direct antiviral activity towards rhinovirus

Filipa Henderson Sousa et al.

PEPTIDES (2017)

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Review Pharmacology & Pharmacy

The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

Xiao C. Li et al.

PHARMACOLOGICAL RESEARCH (2017)

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Article Nutrition & Dietetics

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

Naghmeh Mirhosseini et al.

NUTRIENTS (2017)

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Review Medicine, General & Internal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Adrian R. Martineau et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Review Medicine, General & Internal

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Adrian R. Martineau et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Microbiology

Mechanisms of Action of Vitamin D as Supplemental Therapy for Pneumocystis Pneumonia

Guang-Sheng Lei et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

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Review Medical Laboratory Technology

Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer

Surojit Sarkar et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2016)

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Article Oncology

Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier

Yong-Yan Shi et al.

MOLECULAR MEDICINE REPORTS (2016)

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Article Gastroenterology & Hepatology

Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis

Milica Bozic et al.

JOURNAL OF HEPATOLOGY (2016)

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Article Nutrition & Dietetics

Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

Edwin Hoe et al.

NUTRIENTS (2016)

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Review Medicine, General & Internal

Effect of vitamin D supplementation on inflammation: protocol for a systematic review

Aya Mousa et al.

BMJ OPEN (2016)

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Article Multidisciplinary Sciences

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation

Mahdi Shahmiri et al.

SCIENTIFIC REPORTS (2016)

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Review Medicine, General & Internal

Vitamin D for the management of asthma

Adrian R. Martineau et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2016)

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Article Dermatology

Mitochondrial and lipogenic effects of vitamin D on differentiating and proliferating human keratinocytes

Marco Consiglio et al.

EXPERIMENTAL DERMATOLOGY (2015)

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Review Chemistry, Medicinal

Vitamin-D in the Immune System: Genomic and Non-Genomic Actions

Aikaterini I. Trochoutsou et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2015)

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Article Respiratory System

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

Rachel C. A. Dancer et al.

THORAX (2015)

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Review Nutrition & Dietetics

Modulation of the Immune Response to Respiratory Viruses by Vitamin D

Claire L. Greiller et al.

NUTRIENTS (2015)

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Article Nutrition & Dietetics

1,25-Dihydroxyvitamin D3/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration

Carolyn J. Ricciardi et al.

EUROPEAN JOURNAL OF NUTRITION (2015)

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Article Multidisciplinary Sciences

Vitamin D Supplementation for Childhood Asthma: A Systematic Review and Meta-Analysis

Bruno D. Riverin et al.

PLOS ONE (2015)

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Review Multidisciplinary Sciences

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

Emily K. Calton et al.

PLOS ONE (2015)

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Article Biochemistry & Molecular Biology

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

M. Bonora et al.

CELL DEATH AND DIFFERENTIATION (2014)

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Article Biochemistry & Molecular Biology

TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells

L. Kastl et al.

FEBS LETTERS (2014)

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Article Multidisciplinary Sciences

Effects of Vitamin D on Airway Epithelial Cell Morphology and Rhinovirus Replication

Rebecca A. Brockman-Schneider et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

The Vitamin D Receptor Inhibits the Respiratory Chain, Contributing to the Metabolic Switch that Is Essential for Cancer Cell Proliferation

Marco Consiglio et al.

PLOS ONE (2014)

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Article Nutrition & Dietetics

Calcitriol [1, 25[OH]2 D3] pre- and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells

Drirh Khare et al.

EUROPEAN JOURNAL OF NUTRITION (2013)

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Article Endocrinology & Metabolism

The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D-Resistant Rickets Patients

Dov Tiosano et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

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Article Pathology

Vitamin D: a negative acute phase reactant

Jenna Louise Waldron et al.

JOURNAL OF CLINICAL PATHOLOGY (2013)

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Article Biotechnology & Applied Microbiology

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

Shweta Tripathi et al.

JOURNAL OF GENERAL VIROLOGY (2013)

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Article Immunology

Immunomodulatory Effects of Vitamin D on Innate and Adaptive Immune Responses to Streptococcus pneumoniae

Marie Olliver et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

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Article Endocrinology & Metabolism

VDR Attenuates Acute Lung Injury by Blocking Ang-2-Tie-2 Pathway and Renin-Angiotensin System

Juan Kong et al.

MOLECULAR ENDOCRINOLOGY (2013)

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Article Multidisciplinary Sciences

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

Silke M. Currie et al.

PLOS ONE (2013)

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Review Immunology

The vitamin D receptor and T cell function

Martin Kongsbak et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Pediatrics

Randomized Trial of Vitamin D Supplementation and Risk of Acute Respiratory Infection in Mongolia

Carlos A. Camargo et al.

PEDIATRICS (2012)

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Article Endocrinology & Metabolism

Vitamin D metabolism and signaling in the immune system

John H. White

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2012)

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Review Dermatology

Vitamin D and sepsis An emerginc re ationshio

Jordan A. Kempker et al.

DERMATO-ENDOCRINOLOGY (2012)

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Article Endocrinology & Metabolism

Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2vitarnin D3: Genomic and non-genomic mechanisms

Mark R. Haussler et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

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Article Medicine, General & Internal

Vitamin D and the Immune System

Cynthia Aranow

JOURNAL OF INVESTIGATIVE MEDICINE (2011)

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Review Food Science & Technology

A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency

Gerry K. Schwalfenberg

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Article Multidisciplinary Sciences

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

Peter G. Barlow et al.

PLOS ONE (2011)

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Review Nutrition & Dietetics

Vitamin D and Chronic Lung Disease: A Review of Molecular Mechanisms and Clinical Studies

James D. Finklea et al.

ADVANCES IN NUTRITION (2011)

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Review Pharmacology & Pharmacy

Vitamin D: modulator of the immune system

Femke Baeke et al.

CURRENT OPINION IN PHARMACOLOGY (2010)

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Article Endocrinology & Metabolism

Vitamin D and the Immune System: New Perspectives on an Old Theme

Martin Hewison

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2010)

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Article Peripheral Vascular Disease

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

John P. Forman et al.

HYPERTENSION (2010)

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Review Rheumatology

Vitamin D and inflammation

Xavier Guillot et al.

JOINT BONE SPINE (2010)

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Article Immunology

Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infection: A Randomized, Double-Blinded Trial among Young Finnish Men

Ilkka Laaksi et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Article Urology & Nephrology

Vitamin D: a pleiotropic hormone

Annemieke Verstuyf et al.

KIDNEY INTERNATIONAL (2010)

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Article Multidisciplinary Sciences

Mitochondrial Localization of Vitamin D Receptor in Human Platelets and Differentiated Megakaryocytes

Francesca Silvagno et al.

PLOS ONE (2010)

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Article Endocrinology & Metabolism

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

Kari E. Wong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

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Review Immunology

Vitamin D and respiratory health

D. A. Hughes et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

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Review Allergy

Vitamin D, Respiratory Infections, and Asthma

Adit A. Ginde et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2009)

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Review Endocrinology & Metabolism

Nonclassic Actions of Vitamin D

Daniel Bikle

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Article Immunology

1,25-Dihydroxyvitamin D3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype

Lajos Szeles et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

Jun Tang et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses

John S. Adams et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Critical Care Medicine

Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza

Jesus F. Bermejo-Martin et al.

CRITICAL CARE (2009)

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Article Immunology

Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

Sif Hansdottir et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Urology & Nephrology

Suppression of renin-angiotensin gene expression in the kidney by paricalcitol

Michael Freundlich et al.

KIDNEY INTERNATIONAL (2008)

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Article Nutrition & Dietetics

Vitamin D's role in cell proliferation and differentiation

Sam Samuel et al.

NUTRITION REVIEWS (2008)

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Article Respiratory System

Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3

Sunghan Yim et al.

JOURNAL OF CYSTIC FIBROSIS (2007)

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Article Endocrinology & Metabolism

Mitchondrial dysfunction and age

Kevin E. Conley et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2007)

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Article Biochemistry & Molecular Biology

Constitutive androstane receptor-vitamin D receptor crosstalk:: Consequence on CYP24 gene expression

Amélie Moreau et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Article Immunology

Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation

Sheng Chen et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Biochemistry & Molecular Biology

Vitamin D physiology

P. Lips

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2006)

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Article Multidisciplinary Sciences

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

PT Liu et al.

SCIENCE (2006)

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Article Medicine, Research & Experimental

Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

E Xystrakis et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Article Immunology

Cutting edge:: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression

TT Wang et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Biochemistry & Molecular Biology

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements

PD Thompson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

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Article Immunology

1α,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells

A Boonstra et al.

JOURNAL OF IMMUNOLOGY (2001)

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Article Biochemistry & Molecular Biology

1α,25-dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase

LM Sly et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Critical Care Medicine

Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers - Regulation by interleukin-10

S Lim et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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Article Biochemistry & Molecular Biology

Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system

CM Veldman et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)

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The Role of Vitamin D in Supporting Health in the COVID-19 Era

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