4.7 Review

A Critical Overview of Targeted Therapies for Vestibular Schwannoma

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Summary: Improved diagnostic rate of mosaic NF2 was achieved by targeted deep sequencing of DNA from multiple tissues. Patients with mosaic NF2 showed significant differences in phenotype compared to those with NF2 germline variant, particularly in tumor growth rate and hearing outcome. Schwannoma behavior correlated with the extent of VAF in normal tissues carrying NF2 variant, unlike meningioma.

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Efficacy of aspirin for sporadic vestibular schwannoma: a meta-analysis

Katrina Hannah D. Ignacio et al.

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The SH3PXD2A-HTRA1 fusion transcript is extremely rare in Norwegian sporadic vestibular schwannoma patients

Peter Taule-Sivertsen et al.

Summary: The study aimed to investigate the frequency of SH3PXD2A-HTRA1 fusion gene in vestibular schwannoma patients. Real-time PCR assay showed high sensitivity and detected the fusion transcript in only 1 out of 121 investigated tumors, indicating it is a rare event in this cohort. Further research is needed to determine if the fusion gene is present in other neoplasms.

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Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing

Eric Nisenbaum et al.

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Masazumi Fujii et al.

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Zhiguo Chen et al.

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Yin Ren et al.

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Maria Breun et al.

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Gamma Knife radiosurgery for large vestibular schwannomas greater than 3 cm in diameter

Cheng-Wei Huang et al.

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NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

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Erlotinib for Progressive Vestibular Schwannoma in Neurofibromatosis 2 Patients

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ErbB and Nrg: Potential molecular targets for vestibular schwannoma pharmacotherapy

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