Histamine Causes Pyroptosis of Liver by Regulating Gut-Liver Axis in Mice

Huangjiu usually caused rapid-drunkenness and components such as beta-benzyl ethanol (beta-be), isopentanol (Iso), histamine (His), and phenethylamine (PEA) have been reported linked with intoxication. However, the destructive effect of these components on gut microbiota and liver is unclear. In this study, we found oral treatment of these components, especially His, stimulated the level of oxidative stress and inflammatory cytokines in liver and serum of mice. The gut microbiota community was changed and the level of lipopolysaccharide (LPS) increased significantly. Additionally, cellular pyroptosis pathway has been assessed and correlation analysis revealed a possible relationship between gut microbiota and liver pyroptosis. We speculated oral His treatment caused the reprogramming of gut microbiota metabolism, and increased LPS modulated the gut-liver interaction, resulting in liver pyroptosis, which might cause health risks. This study provided a theoretical basis for the effect of Huangjiu, facilitating the development of therapeutic and preventive strategies for related inflammatory disorders.

Automated summary

In this study, it was found that components in Huangjiu, especially histamine, can increase oxidative stress and inflammatory cytokines in the liver and serum of mice. The gut microbiota community is also affected, with an increase in lipopolysaccharide levels. The study suggests a possible relationship between gut microbiota and liver pyroptosis, and highlights the potential health risks associated with Huangjiu consumption.