期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 35, 页码 6772-6782出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b02199
关键词
AfsumO; SUMOylation; Aspergillus flavus; morphogenesis; aflatoxin; pathogenicity
资金
- National Basic Research Program of China (973 Program) [2013CB127802]
- Natural Science Foundation of Fujian Province [2016J05066]
- Education Department of Fujian Province [JA15170]
- Fujian Agriculture and Forestry University [KF2015045]
Small ubiquitin-like modifiers (SUMOs) can be reversibly attached to target proteins in a process known as SUMOylation, and this process influences several important eukaryotic cell events. However, little is known regarding SUMO or SUMOylation in Aspergillus flavus. Here, we identified a novel member of the SUMO family in A. flavus, AfSumO, and validated the existence of SUMOylation in this pathogenic filamentous fungus. We investigated the roles of AfsumO in A. flavus by determining the effects of AfsumO mutations on the growth phenotype, stress response, conidia and sclerotia production, aflatoxin biosynthesis, and pathogenicity to seeds, and we found that SUMOylation plays a role in fungal virulence and toxin attributes. Taken together, these results not only reveal potential mechanisms of fungal virulence and toxin attributes in A. flavus but also provide a novel approach for promising new control strategies of this fungal pathogen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据