4.7 Review

PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

Contributions of Immune Cells and Stromal Cells to the Pathogenesis of Systemic Sclerosis: Recent Insights

Bingying Dai et al.

Summary: This review summarizes the current knowledge on immune cells and stromal cells in SSc patients and discusses their potential roles in the pathogenesis of SSc, with a focus on recent advances in new subtypes by scRNA-seq.

FRONTIERS IN PHARMACOLOGY (2022)

Review Medicine, General & Internal

Single Cell RNA Sequencing in Autoimmune Inflammatory Rheumatic Diseases: Current Applications, Challenges and a Step Toward Precision Medicine

Tadeja Kuret et al.

Summary: Single cell RNA sequencing (scRNA-seq) is an important technique in life science research that allows analysis of cellular networks and provides indicators for more targeted and personalized therapies. Cellular heterogeneity in complex biological systems, such as the immune system, is a key aspect that highlights the significance of scRNA-seq.

FRONTIERS IN MEDICINE (2022)

Article Biochemistry & Molecular Biology

Systemic Sclerosis: From Pathophysiology to Novel Therapeutic Approaches

Devis Benfaremo et al.

Summary: Systemic sclerosis (SSc) is an immune-mediated chronic disorder characterized by small vessel alterations and fibrosis of the skin and internal organs. Various molecular pathways are being evaluated as potential therapeutic targets for SSc in clinical trials.

BIOMEDICINES (2022)

Review Biochemistry & Molecular Biology

PDGF receptor mutations in human diseases

Emilie Guerit et al.

Summary: PDGFRA and PDGFRB are classical proto-oncogenes encoding receptor tyrosine kinases, with mutations linked to various tumors and diseases. Research has validated the effectiveness of tyrosine kinase inhibitors targeting PDGF receptors, such as imatinib, as a treatment for certain conditions.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Rheumatology

Scleroderma epidemiology update

Leonardo Martin Calderon et al.

Summary: Global epidemiological studies on systemic sclerosis (SSc) show regional variations in prevalence, with the highest rates found among indigenous peoples in Canada. Age and sex differences influence disease severity and presentation. Future research may focus on personalized patient care and identifying high-risk populations for clinical trials.

CURRENT OPINION IN RHEUMATOLOGY (2021)

Review Medical Laboratory Technology

Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition

Fabian A. Mendoza et al.

Summary: Systemic sclerosis is an autoimmune disease characterized by uncontrolled fibrotic processes involving skin and internal organs. The molecular mechanisms behind the disease are not fully understood, but tyrosine protein kinases, including both receptor-activated and nonreceptor tyrosine kinases, are believed to play a role.

TRANSLATIONAL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry

Marc Kschonsak et al.

Summary: HCMV uses a trimer to bind to PDGFR alpha and TGF beta R3, and the binding of these two receptors is mutually exclusive, indicating that they function as independent entry receptors. Additionally, the interaction between the trimer and PDGFR alpha inhibits PDGFR alpha signaling.
Article Immunology

PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1

Naoko Takamura et al.

Summary: Systemic sclerosis is an autoimmune disease characterized by vasculopathy and excessive fibrosis, with limited treatment options available. Research suggests that abnormal regulation of MCHR1 may play a role in the pathogenesis of SSc, and inhibiting MCHR1 could be a novel therapeutic strategy.

FRONTIERS IN IMMUNOLOGY (2021)

Article Oncology

PDGF-BB promotes vascular smooth muscle cell migration by enhancing Pim-1 expression via inhibiting miR-214

Jinshan Zhou et al.

Summary: Research has shown that the PDGF/miR-214/Pim-1 axis may be a potential target for coronary atherosclerotic heart disease, as PDGF-BB enhances smooth muscle cell migration and Pim-1 is regulated by miR-214 in A7r5 cells. PDGF-BB upregulates Pim-1 expression by suppressing miR-214 expression, while overexpression of miR-214 inhibits PDGF-BB-stimulated Pim-1 expression and cell migration. Additionally, overexpression of Pim-1 can reverse miR-214-mediated inhibition of cell migration by activating STAT3, AKT, and ERK signaling pathways.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs

Iulia Szabo et al.

Summary: Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes characterized by microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms and miRNAs play crucial roles in SSc pathogenesis, offering potential as biomarkers and therapeutic targets.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

The emerging complexity of PDGFRs: activation, internalization and signal attenuation

Madison A. Rogers et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Review Cell Biology

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Natascha Roehlen et al.

Article Rheumatology

Circulating biomarkers of systemic sclerosis - interstitial lung disease

Anna-Maria Hoffmann-Vold et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2020)

Article Rheumatology

Pathogenesis of systemic sclerosis associated interstitial lung disease

Svetlana Nihtyanova et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2020)

Article Multidisciplinary Sciences

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Fiorenza Orlando et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

Article Medicine, General & Internal

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

K. R. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Rheumatology

Shared and distinct mechanisms of fibrosis

Joerg H. W. Distler et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Review Immunology

Agonistic antibodies in systemic sclerosis

Gianluca Moroncini et al.

IMMUNOLOGY LETTERS (2018)

Review Biochemistry & Molecular Biology

PDGF in organ fibrosis

Barbara Mara Klinkhammer et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Review Biochemistry & Molecular Biology

The PDGF/PDGFR pathway as a drug target

Natalia Papadopoulos et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Review Biotechnology & Applied Microbiology

Developments in the management of advanced soft-tissue sarcoma - olaratumab in context

Gianluca Moroncini et al.

ONCOTARGETS AND THERAPY (2018)

Article Cell Biology

Different PDGF Receptor Dimers Drive Distinct Migration Modes of the Mouse Skin Fibroblast

Kohta Yamada et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Rheumatology

Update of EULAR recommendations for the treatment of systemic sclerosis

Otylia Kowal-Bielecka et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Review Genetics & Heredity

PDGFs and their receptors

Andrius Kazlauskas

Review Immunology

Genomic and genetic studies of systemic sclerosis: A systematic review

Paraskevi Chairta et al.

HUMAN IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A

Sandra Markovic-Mueller et al.

STRUCTURE (2017)

Article Biochemical Research Methods

Characterization of binding and quantification of human autoantibodies to PDGFRα using a biosensor-based approach

Gianluca Moroncini et al.

ANALYTICAL BIOCHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Structural and biochemical studies of the PDGFRA kinase domain

Ling Liang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Oncology

PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice

Radiosa Gallini et al.

EXPERIMENTAL CELL RESEARCH (2016)

Article Multidisciplinary Sciences

Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis

Alisa A. Mueller et al.

NATURE (2016)

Article Medicine, General & Internal

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Biochemistry & Molecular Biology

Platelet-derived growth factors and their receptors: Structural and functional perspectives

Po-Han Chen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Article Multidisciplinary Sciences

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Ann Hye-Ryong Shim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Cell Biology

Role of platelet-derived growth factors in physiology and medicine

Johanna Andrae et al.

GENES & DEVELOPMENT (2008)

Review Immunology

Pathogenic autoantibodies in systemic sclerosis

Armando Gabrielli et al.

CURRENT OPINION IN IMMUNOLOGY (2007)

Article Biochemistry & Molecular Biology

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

Satoru Yuzawa et al.

Review Biochemistry & Molecular Biology

PDGF signaling in cells and mice

M Tallquist et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2004)

Article Cell Biology

Regulation of c-myc expression by PDGF through Rho GTPases

M Chiariello et al.

NATURE CELL BIOLOGY (2001)