期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms23115916
关键词
natriuretic peptide; growth plate; chondrocyte cell; bone growth; molecular mechanism
资金
- Jacob Randall Foundation
- Nemours Funds
- Institutional Development Award from the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health (NICHD) [1R01HD102545-01A1]
- Austrian MPS society
- A Cure for Robert, Inc.
- Carol Ann Foundation
- Angelo R. Cali & Mary V. Cali Family Foundation, Inc.
- Vain and Harry Fish Foundation, Inc.
- Bennett Foundation
The process of skeletal development in the body, known as endochondral ossification, is regulated by natriuretic peptides, including C-type natriuretic peptide (CNP), which promotes bone growth through various mechanisms.
The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative, hypertrophic to calcified zones. Natriuretic peptides (NPTs) are peptide hormones with multiple functions, including regulation of blood pressure, water-mineral balance, and many metabolic processes. NPTs secreted from the heart activate different tissues and organs, working in a paracrine or autocrine manner. One of the natriuretic peptides, C-type natriuretic peptide-, induces bone growth through several mechanisms. This review will summarize the knowledge, including the newest discoveries, of the mechanism of CNP activation in bone growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据