Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets

The peripheral nervous system (PNS) has a remarkable regenerative capacity in comparison to the central nervous system (CNS), a phenomenon that is impaired during ageing. The ability of PNS axons to regenerate after injury is due to Schwann cells (SC) being reprogrammed into a repair phenotype called Repair Schwann cells. These repair SCs are crucial for supporting axonal growth after injury, myelin degradation in a process known as myelinophagy, neurotropic factor secretion, and axonal growth guidance through the formation of Bungner bands. After regeneration, repair SCs can remyelinate newly regenerated axons and support nonmyelinated axons. Increasing evidence points to an epigenetic component in the regulation of repair SC gene expression changes, which is necessary for SC reprogramming and regeneration. One of these epigenetic regulations is histone acetylation by histone acetyl transferases (HATs) or histone deacetylation by histone deacetylases (HDACs). In this review, we have focused particularly on three HDAC classes (I, II, and IV) that are Zn2+-dependent deacetylases. These HDACs are important in repair SC biology and remyelination after PNS injury. Another key aspect explored in this review is HDAC genetic compensation in SCs and novel HDAC inhibitors that are being studied to improve nerve regeneration.

Automated summary

The peripheral nervous system (PNS) has superior regenerative capacity compared to the central nervous system (CNS). This regenerative ability is attributed to the reprogramming of Schwann cells (SC) into repair Schwann cells, which support axonal growth, myelin degradation, neurotrophic factor secretion, and axonal growth guidance. Epigenetic regulations, particularly histone acetylation and deacetylation, play a crucial role in SC reprogramming and nerve regeneration. This review focuses on Zn2+-dependent histone deacetylases (HDACs) and their importance in repair SC biology and remyelination after PNS injury.